通过NIR照射和瘤微环境刺激控制药物释放的多响应向上转换/有机多孔纳米复合材料
Xiaotao Wang1, Zhihao Bi1, Yonggui Liao2
1Hubei Provincial Key Laboratory of Green Materials for Light Industry, Collaborative Innovation Center for Green Light-weight Materials and Processing, School of Materials Science and Engineering, Hubei University of Technology Wuhan 430068 China.
RSC advances
|January 26, 2026
概括
研究人员使用稀土上转化纳米粒子 (UCNPs) 和多孔开发了新型纳米. 这些基于UCNP的纳米载体能够控制药物释放用于向化疗,结合近红外 (NIR) 光激活和刺激响应性降解.
科学领域:
- 材料科学 材料科学 材料科学
- 纳米技术纳米技术
- 生物医学工程 生物医学工程
背景情况:
- 开发先进的药物输送系统对于有效的癌症治疗至关重要.
- 对刺激有反应的纳米载体具有针对性药物释放和降低毒性的潜力.
- 上转化纳米粒子 (UCNPs) 可以将近红外 (NIR) 光转化为可见/紫外辐射,用于远程激活.
研究的目的:
- 为了合成和描述一种新的有机/无机纳米载体,用于多反应性药物输送.
- 为了研究由NIR照射和特定的生物刺激触发的多克索鲁比辛 (DOX) 的受控释放.
- 评估纳米载体系统在向癌症治疗中的有效性.
主要方法:
- 合成UCNP芯片,涂上含有二硫化键的半孔性有机贝.
- 在纳米载体表面上植入光响应性亚博衍生物.
- 对多克索鲁比 (DOX) 的加载和在各种刺激下 (pH,谷氨,NIR光) 释放的评估.
- 使用蓝法和释放动力学分析 (贝克-隆斯代尔模型) 量化纳米载体降解.
- 在体外细胞测试以评估药物释放和瘤细胞切除功效.
主要成果:
- 成功合成了基于UCNP的纳米囊,具有多孔的有机贝.
- 为多克索鲁比 (DOX) 实现了12.2%的高药物载荷能力.
- 经过刺激反应的DOX释放,在中性pH下泄漏最小,在复合刺激下释放最大.
- 通过协同刺激 (NIR照射,酸性,富含GSH的环境) 在体外证实了有效的瘤细胞切除.
结论:
- 开发的纳米载体平台为有针对性的按需化疗提供了一种多功能方法.
- 基于UCNP的光反应性,GSH触发的降解和光活性表面封闭的结合使药物能够精确地输送.
- 这种多反应系统显示出低毒性,高效的癌症治疗的前景.
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