儿童不良经历和关节炎风险:探索行为风险因素监测系统中的行为和心理调解者
Qinxin Zhou1, Jianzeng Shen1, Dongdong Cao2
1Department of Orthopaedic Surgery, Shaoxing Hospital of Traditional Chinese Medicine Affiliated to Zhejiang Chinese Medical University, Shaoxing, China.
Frontiers in public health
|January 26, 2026
概括
童年不良经历 (ACE) 在成年人中显著增加关节炎风险. 这种联系部分是由吸烟和抑郁症解释的,这突出了解决关节炎预防早期逆境的必要性.
科学领域:
- 公共卫生 公共卫生
- 流行病学 流行病学
- 心理社会医学 心理社会医学
背景情况:
- 童年不良经历 (ACE) 与各种慢性健康状况有关.
- 了解连接ACE与关节炎的途径对于有针对性的干预至关重要.
研究的目的:
- 研究美国成年人ACE和关节炎之间的关联.
- 探索吸烟和抑郁症在ACE-关节炎关系中的调解作用.
主要方法:
- 分析了2023年行为风险因素监测系统 (BRFSS) 对32,594名成年人的数据.
- 根据人口,社会经济和行为因素调整后的物流回归模型.
- 基于反事实的调解分析,以评估吸烟和抑郁症的影响.
主要成果:
- 在ACE和关节炎患病率之间观察到剂量反应关系.
- 与没有ACE的人相比,有4个或更多ACE的人患关节炎的几率比没有ACE的人高55%.
- 吸烟和抑郁症部分调解了这种关联,分别解释了8.70%和25.00%的效果.
结论:
- ACEs与关节炎的几率增加有显著的关联.
- 吸烟和抑郁症是从ACE到关节炎的途径中的部分调解者.
- 解决早期的逆境对于旨在减少关节炎风险的公共卫生战略至关重要.
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