相关实验视频

Updated: Jan 27, 2026

Author Spotlight: Exploring Photodynamic Therapy with Curcumin in a Murine Model for Oral Candidiasis

Author Spotlight: Exploring Photodynamic Therapy with Curcumin in a Murine Model for Oral Candidiasis

Published on: October 27, 2023

在牙周炎中比较臭氧治疗和抗菌光动力学治疗:一项随机临床试验

Shilpi Mangal¹, Shalini Kaushal¹, Nand Lal¹

¹Department of Periodontology, Faculty of Dental Sciences, King George's Medical University, U.P., Lucknow, India.

Journal of oral biology and craniofacial research

|January 26, 2026

概括

臭氧治疗 (OT) 与缩放和根平整 (SRP) 结合,显著改善了牙周炎的管理,超过了抗菌光动力学治疗 (aPDT) 加上SRP. 在这个随机试验中,OT显示出卓越的临床和微生物改善.

科学领域:

牙科牙科是指牙科的专业.
牙周病学牙周病学
微生物学微生物学

背景情况:

牙周炎的管理往往需要扩展和根平整 (SRP) 的辅助疗法.
臭氧疗法 (OT) 和抗菌光动力学疗法 (aPDT) 正在成为潜在的辅助药物.
在牙周炎中,OT和aPDT与SRP一起对OT和aPDT的比较有效性需要进一步研究.

研究的目的:

为了比较OT和aPDT作为SRP补充治疗对牙周炎的疗效.
为了评估临床结果,炎症生物标志物 (IL-1β,PTX-3) 和微生物负载.
确定用于牙周炎管理的优质辅助疗法.

主要方法:

一个单盲,随机对照试验,涉及36名患有III期B级牙周炎的患者.
患者被分为三个组:单独使用SRP,使用SRP+OT和使用SRP+aPDT.
临床参数,生化标志物和微生物计数在基线,1个月和3个月被评估.

主要成果:

SRP + OT组在斑块指数 (PI),牙指数 (GI),探测口袋深度 (PPD) 和临床附着水平 (CAL) 中表现出显著更大的改善.
SRP + OT有效地减少了关键的牙周病原体,如 * Porphyromonas gingivalis * 和 * Tannerella forsythia *.
在SRP+aPDT中,表现出对*Fusobacterium nucleatum*和*Prevotella intermedia*的优异抑制.

结论:

作为SRP的附加剂,OT和aPDT都随着时间的推移改善了牙周炎参数.
与单独的SRP或SRP + aPDT相比,SRP + OT在所有评估参数中始终表现出优异的改进.
臭氧治疗正在成为治疗牙周炎的高效辅助治疗方法.

关键词:

印ocyanine绿色染料介导的抗微生物光动力学治疗.炎症生物标志物炎症生物标志物互乐金-1β是其中的一种.臭氧治疗是一种臭氧疗法.潘特拉辛-3是什么意思?牙周病是指牙周病的发生.定量聚合酶连锁反应的量化反应.

更多相关视频

An In Vitro Approach to Photodynamic Therapy

An In Vitro Approach to Photodynamic Therapy

Published on: August 17, 2018

Adjunctive Diode Laser Therapy and Probiotic Lactobacillus Therapy in the Treatment of Periodontitis and Peri-Implant Disease

Adjunctive Diode Laser Therapy and Probiotic Lactobacillus Therapy in the Treatment of Periodontitis and Peri-Implant Disease

Published on: May 9, 2022

相关概念视频

Clinical Trials

Clinical Trials

Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...

Treating Helicobacter pylori in Peptic Ulcers: Antimicrobial Therapy

Treating Helicobacter pylori in Peptic Ulcers: Antimicrobial Therapy

Helicobacter pylori, a resilient gram-negative bacterium, can thrive in the stomach's harsh, acidic environment. Infection with H. pylori leads to a cascade of events within the stomach lining. One of the critical disruptions caused by this bacterium is the interference with somatostatin production, a hormone responsible for regulating acid secretion. This interference tips the balance, escalating acid secretion and diminishing bicarbonate levels. This imbalance compromises the defensive...

Gene Therapy

Gene Therapy

Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...

Clinical Trials: Overview

Clinical Trials: Overview

Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...

Group Therapy

Group Therapy

Group therapy is a sociocultural approach to psychological treatment, where individuals with shared psychological challenges come together under the guidance of a mental health professional. This therapeutic modality offers unique opportunities for individuals to connect, share, and grow within the context of a supportive group. By fostering mutual understanding and collaboration, group therapy can address a range of psychological concerns effectively, often complementing or surpassing the...

Psychodynamic Therapy

Psychodynamic Therapy

Psychodynamic therapies emphasize the exploration of unconscious processes and early childhood experiences as fundamental contributors to psychological difficulties. These therapies, deeply rooted in Freud's psychoanalytic theory, aim to uncover and resolve unconscious conflicts, granting individuals insights that promote emotional and behavioral healing. Contemporary psychodynamic approaches have evolved, integrating a broader range of influences and methodologies while still valuing the...