非洲猪瘟中的宿主-病原体相互作用:从病毒进入到全身疾病进展
Danyang Zhang1, Shilei Zhang1, Fayu Yang1
1State Key Laboratory of Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730046, Gansu, China.
Cell insight
|January 26, 2026
概括
非洲猪瘟病毒 (ASFV) 在猪中引起致命的疾病. 了解ASFV复制和免疫逃避对于开发有效的疫苗和抗病毒药物来保护全球粮食安全至关重要.
科学领域:
- 病毒学 病毒学
- 免疫学 免疫学 免疫学
- 兽医医学 兽医医学 兽医医学
背景情况:
- 非洲猪瘟 (ASF) 是一种高度传染性和致命的流血性疾病.
- 非洲猪瘟病毒 (ASFV) 是一个大型的,双链DNA病毒,负责ASF.
- 目前控制ASF的挑战源于缺乏有效的疫苗和抗病毒药物.
研究的目的:
- 综合目前关于ASFV复制机制的知识.
- 阐明ASFV逃避宿主免疫防御的策略.
- 为了将病毒机制与宿主损伤和疾病病理相关联.
主要方法:
- 关于ASFV复制和病变的综合文献综述.
- 分析宿主-病原体相互作用和免疫逃避策略.
- 分子,临床和病理数据的整合.
主要成果:
- ASFV采用复制和宿主免疫逃避的复杂机制.
- 了解这些机制是ASFV病变的关键.
- 在ASFV复制和免疫逃避方面仍然存在重大知识差距.
结论:
- 对ASFV复制和免疫规避的进一步研究至关重要.
- 这些知识对于开发新型疫苗和抗病毒疗法至关重要.
- 解决这些差距将促进全球猪产量和粮食安全.
相关概念视频
Immune Response Against Viral Pathogens
1.9K
The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
1.9K
Types of Fever
1.2K
Fever can be triggered by several factors, including infections, nervous system disorders, certain cancers, blood diseases like leukemia, embolism, thrombosis, heatstroke, dehydration, surgical trauma, crushing injuries, and allergic reactions.
Here are the different types of fever:
Here are the different types of fever:
1.2K
Patterns of Fever
3.8K
Before understanding the types and patterns of fever, it is essential to know its phases.
3.8K
Viral Structure
74.4K
Viruses are extraordinarily diverse in shape and size, but they all have several structural features in common. All viruses have a core that contains a DNA- or RNA-based genome. The core is surrounded by a protective coat of proteins called the capsid. The capsid is composed of subunits called capsomeres. The capsid and genome-containing core are together known as the nucleocapsid.
74.4K
Methods of reducing fever
1.3K
The signs and symptoms of fever include hot and dry skin, flushed face, thirst, muscle aches, anorexia, headache, tachycardia, tachypnea, and fatigue. Elevated body temperature is reduced using two methods: pharmacological and nonpharmacological. Proper identification and treatment of the root cause of a fever is of utmost importance.
Pharmacological Methods of Reducing Fever:
Pharmacological Methods of Reducing Fever:
1.3K
Pharmacokinetics: Drug–Food and Drug–Viral Interactions
234
A drug interaction occurs when the concurrent use of another drug, food, or an external substance alters the pharmacological activity of a drug. This interaction can modify the action of the original drug, affecting its effectiveness and safety.Drug–food interactions are significant as they impact drug absorption, metabolism, and excretion. For example, grapefruit juice is a well-known disruptor of drug metabolism. It inhibits the cytochrome P450 3A4 enzyme, crucial for the metabolism of...
234


