在使用可穿戴设备的抗LGI1自身免疫脑炎患者中评估发作负担和治疗疗效:试点可行性研究
Jie Cui1,2, Andrea Duque-Lopez1, Gabriella Brinkmann1
1Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA.
BMJ neurology open
|January 26, 2026
概括
可穿戴设备可以客观地监测抗白丰富的质瘤无活化1 (抗LGI1) 自体免疫脑炎 (AIE) faciobrachial dystonic发作 (FBDS). 这项技术有望改善诊断和治疗评估,特别是在睡眠期间.
科学领域:
- 神经学 神经学
- 生物医学工程 生物医学工程
- 可穿戴技术可穿戴技术
背景情况:
- 抗氨酸丰富的质瘤无活化1 (anti-LGI1) 自免疫脑炎 (AIE) 往往呈现出微妙的面部肌性发作 (FBDS).
- 传统的发作监测方法,如医院内脑电图和患者日记,都有局限性,特别是在夜间发作时.
- 需要客观的,现实世界的监测来准确评估反LGI1 AIE中的FBDS.
研究的目的:
- 评估使用Empatica E4可穿戴设备对抗LGI1 AIE患者FBDS相关运动和自主活动的客观监测的可行性.
- 评估可穿戴技术在睡眠期间检测发作的潜力.
- 探索可穿戴数据的实用性,以评估抗LGI1 AIE中的治疗反应.
主要方法:
- 一项试点研究涉及7名抗LGI1AIE患者和4名对照患者.
- 使用的可穿戴设备 (Empatica E4) 记录,包括加速度计 (ACC),电皮活动 (EDA),光聚光学 (PPG) 和皮肤温度.
- 开发了一个支持向量机算法,使用ACC和EDA功能,专注于睡眠周期的分析.
主要成果:
- 两名患者的治疗前记录显示,与对照人群相比,运动事件,ACC大小和EDA活性显著增加.
- 治疗后的记录显示这些指标显著减少,与临床改善相关.
- 在其他患者中观察到可变的结果,受治疗时间和信号质量的影响.
结论:
- 可穿戴技术是可行的客观,现实世界的监测在反LGI1 AIE.
- 用可穿戴设备进行夜间监测可以提供低噪音的基线来检测活动.
- 这种方法可以提高诊断,治疗评估,并减少对住院监测的依赖.
更多相关视频
05:56Evaluation of the Feasibility, Safety, and Accuracy of an Intraoperative High-intensity Focused Ultrasound Device for Treating Liver Metastases
Published on: January 9, 2019
8.3K
15:00Setup of Consumer Wearable Devices for Exposure and Health Monitoring in Population Studies
Published on: February 3, 2023
3.0K
相关概念视频
Pilot and Numeric Relaying
487
Pilot relaying is a type of differential protection used in power systems. It compares electrical quantities at the terminals of equipment via a communication channel instead of direct relay interconnection. This method is essential for transmission lines where the terminals are far apart, typically up to 80 km for lines with 69 to 115 kV ratings. Four types of communication channels are used for pilot relaying:
487
Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF
531
Tumor Necrosis Factor (TNF), a proinflammatory cytokine, contributes significantly to the inflammation seen in Crohn's disease. It exists as soluble TNF and membrane-bound TNF, with actions mediated through TNF receptors (TNFR). TNFR activation leads to the release of proinflammatory cytokines, T-cell activation, collagen production, and leukocyte migration, all contributing to inflammation in Crohn's disease. Anti-TNF monoclonal antibodies, namely infliximab (Remicade), adalimumab...
531
Seizures: Classification
1.5K
Epilepsy is primarily characterized by unpredictable seizures, either provoked by an identifiable factor, such as injury or illness, or unprovoked, occurring spontaneously without apparent cause.
Seizures are typically classified into two main categories: focal and generalized seizures.
Focal Seizures
Focal seizures originate from specific regions of the brain. These seizures are further sub-classified into two types:
Seizures are typically classified into two main categories: focal and generalized seizures.
Focal Seizures
Focal seizures originate from specific regions of the brain. These seizures are further sub-classified into two types:
1.5K
Self-Efficacy
219
Self-efficacy is the belief in one's capacity to organize and execute actions necessary to manage prospective situations. This belief significantly influences how individuals approach goals, tasks, and challenges across different domains of life.Psychological and Educational ImpactsIndividuals with strong self-efficacy are more resilient in the face of difficulties. They are more likely to adopt effective problem-solving strategies, persist through obstacles, and regulate emotions such as...
219
Autoimmune Disorders
1.7K
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
Concept and Mechanism of Autoimmune Diseases
The immune...
1.7K
Epilepsy and Seizures: Overview
1.3K
Epilepsy is a chronic neurological disease marked by recurrent, unpredictable seizures. These seizures are caused by abnormal electrical discharges in the brain, leading to behavior, sensation, or consciousness alterations. They can also cause transient impairment of awareness, interfering with daily activities.
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
1.3K
