益生菌用于管理非酒精性脂肪肝疾病:疗效和机制性见解
Supriyo Ghosh1, Amlan Jyoti Ghosh1,2, Manab Deb Adhikari3
1Immunology and Microbiology Laboratory, Department of Zoology, University of North Bengal, Siliguri, West Bengal India.
益生菌有望通过改善肠道健康和肝功能来治疗非酒精性脂肪性肝病 (NAFLD). 需要进一步的研究来确认这种情况的最佳使用.
科学领域:
- 胃肠病学 胃肠病学
- 肝病学 肝病学是一种肝病学.
- 微生物学 微生物学
背景情况:
- 非酒精性脂肪性肝病 (NAFLD) 涉及过多的肝脏脂肪积累.
- 传统的NAFLD治疗有潜在的副作用.
- 益生菌正在成为NAFLD的潜在治疗策略.
研究的目的:
- 审查益生菌在管理NAFLD中的治疗潜力.
- 探索益生菌可以使NAFLD患者受益的机制.
- 为了突出进一步临床试验的需要.
主要方法:
- 审查关于益生菌和NAFLD的科学文献.
- 对研究益生菌对肠道微生物群和肝酶的影响的研究分析.
- 检查有关益生菌对脂质代谢和氧化应激的影响的研究.
主要成果:
- 益生菌可以增强有益的微生物代谢物 (例如,SCFA,) 和调节肠道微生物群.
- 益生菌补充与改善肝酶概况和减少肝损伤有关.
- 益生菌可以积极影响脂质代谢,减少肝脏脂肪,并提高抗氧化剂状态.
- 益生菌可以恢复肠道完整性,减少氧化应激,防止内毒素转移.
结论:
- 益生菌补充剂为NAFLD管理提供了一个有希望的低风险方法.
- 像Lactobacillus和Bifidobacterium这样的特定菌株显示出潜力.
- 大规模的长期随机对照试验对于制定NAFLD中益生菌使用的最终指导方针至关重要.
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