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Updated: Jan 28, 2026

Anticancer Efficacy of Photodynamic Therapy with Lung Cancer-Targeted Nanoparticles
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pH-可激活的基于纳米颗粒的工程选择性hexokinase 2降解剂引起GSDME-依赖的癌症治疗的pyroptosis

Linlin Gong1,2, Shasha Li1,2, Jiahui Sun1,2

  • 1Research & Development Institute of Northwestern Polytechnical University in Shenzhen, Shenzhen 518057, China.

Acta pharmaceutica Sinica. B
|January 26, 2026
PubMed
概括

这项研究引入了可以通过pH激活的纳米粒子PROTACs (纳米PROTACs),可以在瘤中选择性降解hexokinase 2 (HK2). 纳米-PROTACs通过触发 pyroptosis 和抑制瘤生长和转移来增强癌症治疗.

关键词:
有氧糖溶解是有氧的.癌症治疗治疗 癌症治疗六甲基酶 2 基酶 2纳米-PROTACs 的使用纳米颗粒是如何形成的聚乙烯胺氨酸的聚乙烯胺氨酸.热灭菌的发生.有针对性的蛋白质降解降解.

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