结膜微血管密度在糖尿病视网膜病变中的临床意义:基于扫描源光学一致性断层扫描血管图的多模式相关性研究
Xiaoli Huang1,2, Jiajia Yu1,2, Wenjun Zou2
1Department of Ophthalmology, The First Affiliated Hospital of Nanjing Medical University, Nanjing City, Jiangsu Province, China, njmu.edu.cn.
Journal of diabetes research
|January 26, 2026
概括
使用扫描源光学连贯性断层扫描血管学 (SS-OCTA) 的结膜微血管评估显示,糖尿病视网膜病变 (DR) 患者的血管密度降低. 这种方法为评估视网膜状况提供了一个切实可行的替代方案,当 fundus 可视化受到损害时.
科学领域:
- 眼科医生 眼科 眼科
- 糖尿病学 糖尿病学
- 医疗成像医学成像
背景情况:
- 糖尿病视网膜病变 (DR) 诊断是媒体不透明的挑战.
- 结膜微血管评估被探索为视网膜病理的潜在指标.
研究的目的:
- 调查使用SS-OCTA的结结膜微血管评估是否可以表明糖尿病患者的视网膜病理.
- 在DR.中,将结膜血管密度 (VD) 与视网膜损伤相关联.
主要方法:
- 对163名糖尿病患者 (110名DR患者) 和49名对照者的比较研究.
- 用SS-OCTA和标准OCTA测量结膜膜和视网膜的VD.
- 对质细胞复合体 (GCC) 和统计相关性的分析.
主要成果:
- 结膜VD随着DR的严重程度逐渐减少,特别是在部区域.
- 时间性结膜性静脉疾病与视网膜损伤,血流减少和神经层较薄相关.
- 在对照组和没有DR的糖尿病之间没有显著的VD差异,表明对视网膜病变的特异性.
结论:
- SS-OCTA结膜VD评估提供了关于视网膜状况的有用信息,在DR中, fundus可视化不佳.
- 当传统的视网膜成像被介质不透明度所阻碍时,这种技术是一种实用的替代方案.
- 结膜微血管评估显示,作为DR进展的非侵入性生物标志物具有前途.
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