快速HPLC分析三种抗瘤药物的药物剂量
Monica Denisa Elena Popescu1, Costel-Valentin Manda1, Johny Neamțu1
1Faculty of Pharmacy, University of Medicine and Pharmacy of Craiova, Romania.
Current health sciences journal
|January 26, 2026
概括
一种新的HPLC方法可以同时量化药物配方中的epirubicin,olaparib和ribociclib. 这种经过验证的方法确保了对这些重要的抗癌药物的准确分析.
科学领域:
- 分析化学 分析化学
- 药品分析 药品分析
背景情况:
- 埃皮鲁比 (环素),奥拉巴里布 (PARP抑制剂) 和里博西基布 (CDK4/6抑制剂) 是主要的抗癌药物.
- 在生物流体和剂量形式中准确的量化对于治疗疗效至关重要.
研究的目的:
- 开发和验证一种快速的高性能液态染色法 (HPLC) 方法,用于同时量化epirubicin,olaparib和ribociclib.
- 应用在药物剂型中分析这些药物的方法.
主要方法:
- 在Vanquish核心系统上使用光二极管阵列 (PDA) 检测的HPLC.
- 使用Oasis PRiME HLB®弹使用固相提取 (SPE) 进行样本制备.
- 在一个多孔的石墨碳柱 (HypercarbTM) 上进行色谱分离,并进行梯度化 (乙/四).
主要成果:
- 建立了一个快速高效的HPLC-PDA方法,用于同时分析.
- 该方法根据欧洲药物管理局 (EMA) 的指导方针显示出出色的验证数据,包括稳定性,LOD/LOQ,精度,准确性和线性.
- 该方法在制药剂型分析中的成功应用.
结论:
- 本文介绍的HPLC-PDA方法提供了一种可靠和验证的方法,用于同时量化epirubicin,olaparib和ribociclib.
- 该方法适用于药物配方中这些重要的抗癌药物的常规质量控制和分析.
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