在激进囊切除术中实现Pentafecta的预测因素和瘤结果:一个元分析
Zhiqiang Zeng1, Wubin Chen1, Wangbing Chen1
1Santai People's Hospital (Santai Hospital Affiliated to North Sichuan Medical College), Mianyang, Sichuan, China.
Frontiers in oncology
|January 26, 2026
概括
RC-Pentafecta显著预测了激进囊切除术 (RC) 后的整体存活率 (OS) 和癌症特异性存活率 (CSS). 关键预测因素包括患者年龄,术后健康状况和病理阶段,为改善患者结果提供了宝贵的见解.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 在瘤学瘤学.
- 医学统计 医学统计
背景情况:
- 激进囊切除术 (RC) 是用于膀癌的重大手术.
- 预测RC后的结果对于患者管理至关重要.
- RC-Pentafecta是评估外科手术成功的拟议指标.
研究的目的:
- 评估RC-Pentafecta在RC后的整体存活率 (OS) 和癌症特异性存活率 (CSS) 的预测值.
- 确定与实现RC-Pentafecta相关的术后预测因素.
主要方法:
- 9项回顾性研究 (2020-2025) 的系统综述和元分析.
- 按照PRISMA指南搜索了主要的数据库 (PubMed,Embase,Cochrane,Web of Science) 进行了搜索.
- 采用固定和随机效应模型进行数据合成.
主要成果:
- 实现RC-Pentafecta与改进的操作系统和CSS显著相关.
- 在年龄,住院时间 (LOS),ASA得分,并发症 (糖尿病,高血压),尿路转移类型以及病理T和N阶段之间观察到显著的差异.
结论:
- 在接受RC的患者中,RC-Pentafecta作为OS和CSS的有价值预测器.
- 患者的年龄,术后健康状况 (例如,ASA得分,并发症) 和病理阶段 (pT,pN) 是RC-Pentafecta成就的关键预测因素.
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