病例报告:偶然发现的与HPV相关的宫内腺癌,呈现为假瘤 (pseudomyxoma peritonei)
1Department of clinical medicine, Jining Medical University, Jining, Shandong, China.
Frontiers in oncology
|January 26, 2026
概括
隐藏的人类乳头瘤病毒 (HPV) 相关的宫癌可以模仿卵巢瘤,导致诊断挑战. 免疫组织化学对于区分转移性宫腺癌与原发性卵巢癌至关重要.
科学领域:
- 妇科瘤学 妇科瘤学
- 病理学 病理学 病理学
- 瘤成像学成像学
背景情况:
- 隐藏的人类乳头瘤病毒 (HPV) 相关的内宫腺癌可以呈现异常.
- 双边卵巢转移和伪乳腺瘤 (pseudomyxoma peritonei) 类似的瘤是隐性宫癌的罕见表现.
研究的目的:
- 为了突出隐藏的HPV相关的宫内腺癌所带来的诊断挑战.
- 强调免疫组织化学分析在将转移性与原发性卵巢瘤区分开来时的重要性.
主要方法:
- 卵巢瘤和瘤的组织病理学检查.
- 对于p16,ER,PR,Ki-67,PAX8和WT1.1.的免疫组织化学 (IHC) 进行检测.
- 对临床和成像发现的审查.
主要成果:
- 一名48岁的女性患有隐性HPV相关的宫内腺癌 (Silva模式B) 最初被误诊为原发性卵巢粘膜癌.
- 组织病理学和IHC证实了转移性宫内腺癌 (扩散p16+,ER-/PR-,Ki-67 95%).
- 炎被归因于瘤粘素分泌,没有证据表明尾病变.
结论:
- 隐藏的宫腺癌可以模仿假瘤 (pseudomyxoma peritonei) 和原发性卵巢癌.
- 免疫组织化学标志物 (p16,PAX8,WT1) 对于准确诊断至关重要.
- 多学科的方法对于分类粘膜性瘤和识别罕见的转移性途径,如横管传播至关重要.
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