在头癌中免疫疗法后的顺序救援全身疗法:现实世界的研究
Santiago Cabezas-Camarero1,2, Salomé Merino-Menéndez3, María Nieves Cabrera-Martín4
1Department of Medical Oncology, Instituto de Investigación Sanitaria San Carlos (IdISSC), Hospital Clínico Universitario San Carlos, Madrid, Spain.
Frontiers in oncology
|January 26, 2026
概括
免疫检查点抑制剂 (ICI) 使用基于 cetuximab 的疗法后的救生化疗显示出有前途的响应率和在头部和部复发性/转移性状细胞癌 (SCCHN) 中改善的生存率. 这种方法提供了一个可行的治疗选择ICI后的进展.
科学领域:
- 在瘤学瘤学.
- 头部和部癌症 头部和部癌症
- 免疫治疗是一种免疫疗法.
背景情况:
- 在免疫检查点抑制剂 (ICI) 进展后,没有针对头部和部复发性/转移性状细胞癌 (SCCHN) 的标准治疗方法.
- 在ICI (SCAI) 后的救援化疗显示出可能超过历史数据的性能.
- 基于 cetuximab 的 SCAI 结果在现实环境中进行了评估.
研究的目的:
- 在免疫检查点抑制剂 (SCAI) 后,评估基于 cetuximab 的救援化疗在患有复发性/转移性头和部状细胞癌 (SCCHN) 的患者的疗效和安全性.
- 为了比较SCAI的结果与免疫治疗前的最后一次化疗 (LCBI).
- 评估与基于 cetuximab 的 SCAI 相关的治疗暴露和不良事件.
主要方法:
- 对80名R/M SCCHN.患者的回顾性分析.
- 评估客观反应率 (ORR),反应持续时间 (DoR),目标病变的最佳百分比变化 (PCTL),无进展生存率 (PFS) 和整体生存率 (OS).
- 使用常用术语对不良事件 (CTCAE) 标准对不良事件 (AEs) 的评估 5.0.0.
主要成果:
- 一线SCAI的ORR为59%,中位数DoR为9.4个月,中位数PFS为5.9个月,中位数OS为12.4个月.
- 基于塞图西马布的治疗暴露时间 (256天) 比ICI暴露时间 (168.5天) 长得多.
- 与LCBI (ORR 36%,PFS 8个月) 相比,SCAI显示了更高的ORR (47%),但更短的PFS (4.4个月).
结论:
- 在ICI后的基于cetuximab的SCAI显示了高,持久和深刻的反应率,与历史数据相比,改善了生存率.
- 在重新测序的患者中,SCAI表现出适度的疗效.
- 需要在更大的前性研究中进一步证实.
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