在Carthami Flos中的红杉黄色是通过激活补充物C3引起的Xuebijing注射诱导的立即过敏反应的原因
Wenjing Li1, Yuan Gao1, Jingjing Yan1
1State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100193, China.
Chinese herbal medicines
|January 26, 2026
概括
徐注射 (XBJI) 通过激活补体C3,导致组胺释放,引起非免疫即时过敏反应 (IHR). 在Carthami Flos中,红杉黄色被确定为罪祸首,而脱色的XBJI保留了抗炎性质.
科学领域:
- 药理学 药理学是指药理学的学科.
- 免疫学 免疫学 免疫学
- 传统中国医药 传统中国医药
背景情况:
- 徐注射 (XBJI) 是一种广泛使用的传统中医药,用于治疗败血症和最近的COVID-19.
- 立即过敏反应 (IHR) 是与XBJI相关的主要不良反应.
- 了解XBJI诱导的IHR的分子机制对于患者的安全至关重要.
研究的目的:
- 阐明 XBJI 诱导的 IHR 背后的分子机制.
- 确定负责XBJI引起的IHR的特定组件.
- 评估在解决IHR触发因素后保留抗炎活性的潜力.
主要方法:
- 准备抗XBJI的抗血清,并进行对抗性实验.
- 对XBJI在小鼠中触发系统性IHR的能力的评估.
- 测量关键的炎症媒介 (tIgE,MCPT-1,基因组胺) 和补充激活.
- 在体外评估XBJI对瘤细胞脱粒和巨细胞炎症反应的影响.
主要成果:
- XBJI没有诱导免疫介导的IHR或提高IgE/MCPT-1水平.
- 通过补充C3激活和基因组胺释放,XBJI直接触发IHR,独立于免疫机制.
- 来自Carthami Flos的红杉黄色 (SY) 被确定为XBJI诱导的IHR的主要罪祸首.
- 变色的XBJI没有诱导IHR,并保持了对巨细胞的抗炎作用.
结论:
- XBJI主要通过直接补充C3激活诱导非免疫IHR.
- 红杉黄色是XBJI诱导的IHR的主要组成部分.
- 脱色XBJI可以减轻IHR,同时保持治疗性抗炎功效.
- 这些发现支持IHR的临床管理和XBJI生产的优化.
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