在NSCLCLC中通过免疫组织化学表达CEACAM5的风景
Ying-Han R Hsu1,2, Amna Almutrafi1,3, Katrina Hueniken1
1University Health Network, Princess Margaret Cancer Centre, Toronto, Ontario, Canada.
JTO clinical and research reports
|January 26, 2026
概括
高CEACAM5表达发生在18%的非小细胞肺癌 (NSCLC) 患者中. CEACAM5蛋白水平与NSCLC的预后或常见突变无关.
科学领域:
- 在瘤学瘤学.
- 分子诊断学 分子诊断
- 癌症生物标志物 癌症生物标志物
背景情况:
- 癌胚抗原相关细胞粘附分子5 (CEACAM5) 是非小细胞肺癌 (NSCLC) 的治疗点.
- 之前的研究表明,CEACAM5在约25%的肺腺癌病例中表达高.
- 关于CEACAM5表达率和NSCLC的预后意义,现实世界数据有限.
研究的目的:
- 系统地评估CEACAM5蛋白表达在大规模的现实世界NSCLC患者群体中.
- 评估CEACAM5表达与临床参数的相关性,包括PD-L1状态和驱动突变.
- 为了确定CEACAM5蛋白表达对患者生存的预后影响.
主要方法:
- 在两个NSCLC队列中,通过免疫组织化学评估CEACAM5蛋白表达,使用临床活检和切除样本.
- 三位病理学家将表达率评为高 (≥50%的瘤细胞,≥2+强度),中等 (1-49%的瘤细胞,≥2+强度) 或负 (0/1+强度).
- 统计分析包括评价者间可靠性评估,费舍尔的精确测试,奇平方测试和存活相关性的日志等级测试.
主要成果:
- 在CEACAM5评估的病理学家中观察到适度的interrater可靠性.
- 在NSCLC患者队列中的18%中发现了高CEACAM5表达.
- 在CEACAM5表达和瘤阶段,PD-L1表达,瘤突变负担或EGFR/KRAS突变之间没有发现显著的相关性.
结论:
- 大约18%的NSCLC病例表现出基于免疫组织化学的高CEACAM5表达.
- 在NSCLC中CEACAM5表达水平与瘤驱动突变没有显著关联.
- 在这个NSCLC队列中,CEACAM5蛋白表达没有显示无复发或整体存活的预后价值.
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