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急性躁狂和精神病可能由圣约翰草引发
Daisuke Yoshioka1,2, Takehiko Yamanashi2, Masaaki Iwata2
1Department of Psychiatry Yowa Hospital Yonago Japan.
PCN reports : psychiatry and clinical neurosciences
|January 26, 2026
概括
圣约翰草 (SJW) 可以引起罕见但严重的躁狂和精神病反应,即使在没有先前精神病史的年轻成年人中服用标准剂量. 这一案例凸显了与这种流行的草药补充剂相关的潜在风险.
科学领域:
- 精神病学是一个精神病学.
- 药理学 药理学是指药理学的学科.
- 草药是一种草药.
背景情况:
- 圣约翰草 (SJW) 是一种常见的抑郁症草药补充剂,通常被认为是安全的.
- 罕见的躁狂和精神病反应与SJW有关,通常与高剂量或同时使用精神药物有关.
- 患有精神病史的人可能更容易受到不良影响.
研究的目的:
- 报告一个年轻人患有急性躁狂和精神病症状的病例,使用标准剂量的SJW.
- 突出SJW严重精神反应的潜力,即使在没有显著精神病史的个人中也是如此.
- 强调考虑SJW作为精神病发作潜在触发因素的重要性.
主要方法:
- 一个二十多岁的日本男性的案例报告.
- 详细的临床表现包括情绪不稳定,宏伟/迫害妄想和睡眠减少.
- 诊断工作包括血液检测,脑液分析,脑部成像和抗体检测.
- 用阿里皮普拉治疗和随后停止SJW的治疗.
- 长期跟踪阿里皮普拉长效注射剂和最终停止使用.
主要成果:
- 患者在恢复大学后COVID-19感染后不久就出现了急性躁狂和精神病症状.
- 最初的诊断是精神分裂情绪障碍,在阿里皮普拉治疗后迅速改善.
- 患者报告SJW使用数个月,这表明与症状发作的时间关联.
- 停止SJW和开始抗精神病治疗导致持续的临床稳定性.
- 抗精神病治疗最终在没有症状复发的情况下停止.
结论:
- 急性躁狂和精神病症状可以在服用标准剂量的SJW时,在患有精神病史最小的年轻人中表现出来.
- 这一案例强调,尽管SJW的一般安全性,但严重的精神反应是可能的.
- 临床医生应将SJW视为新出现的躁狂或精神病症状的患者的潜在贡献因素.
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