在怀孕和母乳养期间接触短链PFAS会改变成年期的学习和记忆:可能与大脑发育相关的机制
Luca Lorenzini1,2, Marzia Moretti1, Claudia Zanardello3
1Department of Veterinary Medical Sciences, University of Bologna, Bologna, Italy.
Frontiers in toxicology
|January 26, 2026
概括
母亲暴露于短链和多基基物质 (PFAS),如GenX和PFBA,导致老鼠后代的持久认知缺陷和神经炎症. 这些发现挑战了短链PFAS作为长链PFAS替代品的安全性.
科学领域:
- 环境毒理学环境毒理学
- 神经科学是一个神经科学.
- 发育生物学 发展生物学
背景情况:
- 长链PFAS与认知和行为问题有关.
- 监管限制导致短链PFAS的使用增加.
- 关于短链PFAS神经发育毒性的数据有限.
研究的目的:
- 研究短链PFAS (GenX和PFBA) 的神经发育毒性.
- 提供第一个关于母亲暴露于这些化合物的实验证据.
主要方法:
- 在大鼠模型中,母亲在交配前,怀孕期间和哺乳期暴露于GenX和PFBA.
- 使用莫里斯水迷宫评估后代的认知功能.
- 在活体中对PFBA暴露进行机械研究,以检查神经元成熟和基因表达.
主要成果:
- 后代表现出空间学习和认知灵活性受损.
- 观察到神经元成熟延迟和关键神经元标记物 (MAP2,PSD95,VGLUT) 的表达减少.
- 观察到持续性神经发生障碍,神经炎症和海马体基因表达失调.
结论:
- 短链PFAS可能会破坏大脑发育,导致神经炎症和认知障碍.
- 目前对短链PFAS的安全评估需要重新评估.
- 神经发育终点对于未来的PFAS风险评估和政策至关重要.
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