标准与个体化血压目标在血栓切除术期间:一个随机控制的试验试验
Ulrick S Espelund1,2, Jan B Valentin3, Christian F Eriksen2,4
1Department of Anesthesiology and Intensive Care Horsens Regional Hospital Horsens Denmark.
Stroke (Hoboken, N.J.)
|January 26, 2026
概括
这项针对急性缺血性中风患者的试点研究发现,由于维持目标血压的困难,在内血管治疗期间个性化血压管理是不可行的. 不建议使用当前协议进行进一步的试验.
科学领域:
- 神经学 神经学
- 心血管医学 心血管医学
- 干预性放射学 干预性放射学
背景情况:
- 在急性缺血性中风的内血管治疗期间,最佳的血压管理仍未确定.
- 这项试点研究评估了标准血压目标与个性化血压目标的可行性.
研究的目的:
- 评估两种血压管理策略在接受急性缺血性中风内血管治疗的患者中的可行性.
- 将标准血压目标与基于患者基线的个性化目标进行比较.
主要方法:
- 一个随机控制的试验试验,涉及60名急性缺血性中风和大血管闭塞的成年患者.
- 患者被随机分配到标准 (平均动脉血压 [MABP] 70-90 mm Hg) 或个性化 (MABP ±10%的基线) 目标.
- 主要结局是90天后修改的兰金表得分;次要结局包括可行性指标和再输率.
主要成果:
- 与标准组相比,个性化血压组显示出明显更高的动脉平均血压和缩血压.
- 在不同组中,全转血率相似 (90%对93%).
- 没有达到可行性标准,因为两组都始终保持在目标MABP范围内 (54.3%与61.4%的目标之外的时间).
结论:
- 由于达到目标血压的困难,在这项试点研究中,个性化策略是不可行的.
- 研究结果表明,目前的方案不适合进行更大的试验.
- 需要进一步的研究来完善血管内卒中治疗的血压管理策略.
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