血脑屏障的结构和功能在外科手术期神经认知障碍中
Yipeng Su1,2, Yiting Chen1,2, Bingqi Zheng1,2
1Shengli Clinical Medical College, Fujian Medical University, Fuzhou, China.
Frontiers in neuroscience
|January 26, 2026
概括
在老年手术患者中,外科手术期神经认知障碍 (PND) 是常见的. 血脑屏障 (BBB) 功能障碍是PND的关键因素,为预防和治疗提供了新的目标.
科学领域:
- 神经科学是一个神经科学.
- 老年医学 老年医学
- 手术并发症 手术并发症
背景情况:
- 外科手术期间的神经认知障碍 (PND) 是老年人手术后经常出现的神经并发症.
- 术后发病症与术后残疾和死亡率的增加有关.
- 目前还没有针对PNDs的特定治疗方法.
研究的目的:
- 审查PND发病过程中血脑屏障 (BBB) 变化的最新证据.
- 确定潜在的预防策略和PND治疗目标.
主要方法:
- 系统审查最近关于PND中BBB结构和功能的研究.
- 整合证据,将BBB完整性与PND机制联系起来.
主要成果:
- 血脑屏障 (BBB) 损伤是PNDs发展的关键因素.
- 存在多种PND病变的假设,包括神经炎症和氧化应激.
- BBB的结构和功能变化是PND发展的核心.
结论:
- 在PND的病理机制中,BBB的变化起着重要的作用.
- 了解BBB功能障碍为PND预防和治疗提供了新的途径.
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