在接受心脏手术的患者中,手术前血清肌素变化和急性损伤
Bo Jiang1, Yi Hao2, Meiping Wang3
1Intensive Critical Unit, Beijing Luhe Hospital, Capital Medical University, Beijing, China.
Frontiers in medicine
|January 26, 2026
概括
手术前血清肌素变化影响急性损伤 (AKI) 风险和心脏手术的结果. 负面变化降低了AKI的可能性,但如果AKI发展,死亡率和ICU停留率会增加.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 心脏病学 心脏病学
- 关键护理医学 关键护理医学
背景情况:
- 手术前血清肌素波动在开放心脏手术中很常见.
- 这些波动,术后急性损伤 (AKI) 和患者结局之间的关联需要进一步调查.
研究的目的:
- 评估手术前血清肌素变化 (ΔScr) 和手术后AKI在接受开心手术的患者之间的关联.
- 评估ΔScr对临床结果的影响,包括AKI,严重AKI,AKI无法恢复,住院死亡率和ICU停留时间 (LOS).
主要方法:
- 在560名接受开放心脏手术的患者中进行了回顾性队列研究.
- 手术前血清肌素变化 (ΔScr) 计算为手术前和基线值之间的差异.
- 患者分为负 (<0 mg/dl),正常 (0-0.3 mg/dl) 和升高 (≥0.3 mg/dl) 的 ΔScr 组.
- 用于结果分析的多变量逻辑回归和受限立方线模型.
主要成果:
- 40.2%的患者发生了AKI.
- 增加的 ΔScr 与 AKI,严重的 AKI 和 AKI 不恢复的更高几率相关.
- 在AKI患者中,负 ΔScr 与正常 ΔScr 相比,与更高的住院死亡率和延长的ICU LOS (>72h) 有关.
- 在AKI患者中,升高的ΔScr与不良结果没有显著的关联.
结论:
- 术前阴性血清肌素变化与心脏手术后发展AKI的可能性较低有关.
- 然而,对于患有AKI的患者来说,负 ΔScr 预测了更糟糕的结果,包括更高的住院死亡率和延长ICU停留时间.
- 术前血清肌素变化升高并没有显示与不良结果的显著关联.
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