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机体形态发生的机械化学调节:工程微环境中的集成信号电路

Xinxin Zhang¹, Yuanyuan Zhao¹, Lina Mao¹

¹State Key Laboratory of Advanced Medical Materials and Devices, Engineering Research Center of Pulmonary and Critical Care Medicine Technology and Device (Ministry of Education), Tianjin Key Laboratory of Biomedical Materials, Institute of Biomedical Engineering, Tianjin Institutes of Health Science, Chinese Academy of Medical Science and Peking Union Medical College, Tianjin, 300192, China.

Materials today. Bio

|January 26, 2026

概括

有机体的发育依赖于由细胞信号通路和核力学解码的机械力量. 具有可控粘弹性的工程仿生环境可以增强器官的忠实性和相关性.

科学领域:

生物医学工程生物医学工程
细胞生物学细胞生物学
发展生物学发展生物学

背景情况:

有机体形态发生是由微环境的机械线索调节的.
机械传导通路整合物理刺激来控制细胞行为和组织模式.
核机械转导在将机械输入转化为稳定的表观遗传结果方面发挥着关键作用.

研究的目的:

系统地绘制机械生物学的逻辑,控制器官的发展.
阐明矩阵生物物理学,核力学和染色体组织之间的相互作用.
为设计先进的有机体平台提出一个工程框架.

主要方法:

审查信号架构 (MAPK/PI3K-Akt,Wnt/β-catenin,Hippo-YAP/TAZ) 解码机械输入的情况.
分析涉及细胞骨-LINC复合体和Lamin A.的核机械转导机制.
检查从静态到动态的粘弹性矩阵的多样化培养系统.

主要成果:

机械刺激,如剪切应力,力和矩阵属性,通过特定的信号通路来解码.
核机械传导集成机械信号,影响染色体的可访问性和基因表达.
相互连接的信号网络可以在层次上控制有机体的增殖,谱系的规范和模式.

结论:

有机体的发育是由细胞外和细胞内机械线索的复杂相互作用所决定的.
核力学和染色体重塑对于将短暂的机械信号转化为持续的细胞反应至关重要.
具有可控制机械性能的仿生微环境的工程是开发下一代有机体的关键.

关键词:

细胞微环境是细胞微环境.细胞外矩阵是细胞外矩阵.机械转导是指机械转导的过程.形态发生形态发生形态发生核机械传导核机械传导有机器人机器人机器人机器人

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