人参多糖可通过调节狗的肠道微生物群来改善DSS诱导的炎症性肠病
Liuwei Xie1, Xiao Li2,3, Aipeng Mao4
1College of Police Dog Technology, Criminal Investigation Police University of China, Shenyang, China.
Frontiers in veterinary science
|January 26, 2026
概括
人参多糖有效地通过减少炎症和改善肠道微生物群平衡来治疗犬类炎症性肠病 (IBD). 这种天然化合物对患有这种慢性胃肠道疾病的狗来说是一个有前途的治疗方法.
科学领域:
- 兽医医学 兽医医学 兽医医学
- 胃肠病学 胃肠病学
- 微生物学 微生物学
背景情况:
- 炎症性肠病 (IBD) 是狗中普遍存在的慢性胃肠道疾病,严重影响狗的健康和生活质量.
- 目前对犬类IBD的治疗方法可能存在局限性,需要探索新型治疗剂.
研究的目的:
- 为了评估人参多糖在控制硫酸 (DSS) 诱导的炎症性肠病 (IBD) 在狗中的有效性.
- 在狗IBD模型中评估人参多糖对临床症状,血清参数,结肠组织病理学和肠道微生物群组成的影响.
主要方法:
- 在使用二硫酸 (DSS) 的狗中诱导IBD.
- 给受影响的狗使用人参多糖.
- 监测临床症状,血清生物化学标记物 (包括C反应蛋白) 和结肠组织.
- 使用测序技术分析肠道微生物群的组成和多样性.
- 微生物代谢途径的功能预测.
主要成果:
- 人参多糖治疗显著缓解了临床症状,并改善了DSS诱导的狗IBD的结肠组织病理学.
- 血清生物化学参数显示部分恢复,特别是C反应性蛋白水平的降低.
- 肠道微生物群分析显示,阿尔法多样性增加,并转向更健康的组成,富含有益的属 (例如, *Bacteroides*, *Megamonas*, *Fusobacterium*) 和致病细菌 (例如, *Campylobacter*) 的减少.
- 功能分析表明,人参多糖可以逆转DSS诱导的肠道微生物群中碳水化合物代谢途径的抑制.
结论:
- 人参多糖体在减轻狗狗中DSS诱导的IBD方面表现出治疗效果.
- 该机制涉及调节炎症反应并恢复肠道微生物群的恒常性.
- 人参多糖体代表了一种有前途的天然治疗候选物,用于犬类IBD管理.
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