生物活性和智能修复材料在预防二次的临床有效性:系统性审查和元分析
Abdulaziz Zailai1,2, Ola Mubarki3, Ali N Alobaidan4
1Restorative Dentistry, Jazan Specialized Dental Center, Jazan, SAU.
Cureus
|January 26, 2026
概括
与传统牙相比,生物活性牙材料显著减少了45%的二次. 玻璃离子体水泥 (GIC) 提供了最强的保护,支持在高病风险患者中使用它们.
科学领域:
- 牙科材料科学 牙科材料科学
- 恢复性牙科 恢复性牙科
- 卡里斯研究 研究 卡里斯研究
背景情况:
- 二次性虫是导致牙修复失败的主要原因.
- 生物活性材料释放治疗性离子以促进重矿化和抑制细菌.
- 对生物活性材料与常规材料的临床证据是零碎的.
研究的目的:
- 系统地审查和元分析生物活性修复材料在预防二次的临床疗效.
- 为了比较生物活性材料与常规修复材料在永久牙.
- 评估证据的强度和确性.
主要方法:
- 在PubMed,Scopus,Web of Science,Embase和CENTRAL系统搜索到2025年的RCT.
- 包括比较生物活性材料 (GICs,RMGICs,giomers,生物活性树脂,alkasites) 与常规对照材料 (树脂复合物,合金) 的研究.
- 随机效应的元分析,使用Hartung-Knapp-Sidik-Jonkman调整和试验序列分析 (TSA).
主要成果:
- 分析了40个涉及5506次修复的RCT.
- 生物活性材料显示,二次腐烂风险降低了45% (RR=0.55,p<0.001).
- 玻璃离子体水泥 (GIC) 显示出最强的保护作用 (RR=0.36,p=0.002); 玻璃离子体没有显著的益处 (RR=1.09,p=0.87).
结论:
- 生物活性修复性材料在预防二次腐烂方面优于传统材料.
- 证据是强有力的和确的,支持生物活性材料,特别是GIC和生物活性树脂,用于高虫风险患者.
- 由于某些研究存在偏差风险,证据的确定性中等;未来的研究应该解决机械寿命.
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