冷大气等离子体通过氧驱动的线粒体调节促进口腔软组织的抗炎和再生反应
Tien Ngoc Thuy Nguyen1,2, Byung-Hoon Kim1,2
1Convergence research center for treatment of oral soft tissue disease (MRC), Chosun University, Gwangju 61452, Republic of Korea.
ACS omega
|January 26, 2026
概括
冷大气等离子体 (CAP) 疗法使用活性氧和物种来减少口腔炎症,并通过调节细胞氧化还原平衡和线粒体功能来促进组织愈合.
科学领域:
- 生物医学工程 生物医学工程
- 口腔生物学 口腔生物学
- 血医学是一种血医学.
背景情况:
- 寒冷大气等离子体 (CAP) 正在探索口腔软组织再生和炎症控制.
- 了解底层机制,特别是氧化还原和线粒体调节,对于治疗应用至关重要.
研究的目的:
- 研究基于的CAP如何影响脂聚糖 (LPS) 挑战的人类牙纤维细胞 (HGF-1) 中的氧化还原平衡和线粒体功能.
- 阐明反应性氧和物种 (RONS) 和过氧化 (H2O2) 在介导CAP的抗炎和再生作用中的作用.
主要方法:
- 人类牙纤维细胞 (HGF-1) 用LPS进行刺激,并用CAP处理.
- 光学发射光谱学和红外热学特征等离子体.
- 评估了细胞内H2O2水平,NF-κB激活,炎症性细胞因子分泌 (IL-6,IL-1β,TNF-α),原I表达,细胞迁移,增殖和线粒体功能 (ROS,膜潜力,生物发生).
- catalase被用来确认H2O2.2.的作用.
主要成果:
- CAP产生了一个富含RONS的非热等离子体羽毛.
- CAP在没有细胞毒性的情况下暂时增加了H2O2,恢复了氧化还原平衡并抑制了氧化应激.
- CAP减弱了LPS诱导的NF-κB激活,并减少了IL-6,IL-1β和TNF-α的分泌.
- CAP增强了 I 原表达,细胞迁移和增殖,表明向再生转变.
- CAP激活了PGC-1α/NRF-1/TFAM通路,改善了线粒体功能并促进了生物发生.
- 催化酶治疗消除了CAP的作用,证实H2O2是关键的介质.
结论:
- CAP是一种非药理学,氧化还原调节的工具,用于口腔软组织炎症和再生.
- CAP集成氧化和线粒体信号,以解决炎症并促进愈合.
- 在这种情况下,过氧化被确定为CAP治疗效果的中心调解剂.
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