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David Picado-Tejero¹, Laura Mendoza-Cerezo^1,2, Jesús M Rodríguez-Rego¹

¹Departamento de Expresión Gráfica, Escuela de Ingenierías Industriales, Universidad de Extremadura, Avenida de Elvas, s/n, 06006 Badajoz, Spain.

|January 26, 2026

概括

这项研究引入了一种来自食品级多糖的新型生物墨水,用于3D生物打印. 开发的水凝为生物相容组织工程应用提供可调节的特性.

科学领域:

生物材料科学生物材料科学
组织工程是组织工程.
生物打印技术的技术

背景情况:

开发功能性和生物相容的生物墨水对于组织工程至关重要.
自然聚合物为生物油墨配方提供可持续的替代品.
在实现3D生物打印所需的质和机械性能方面存在挑战.

研究的目的:

设计和评估一种使用食品级多糖的新型生物油墨配方.
为了确定 κ - 卡拉基安南 (KC),特拉加康 (TG) 和康雅克葡萄干南 (KG) 的最佳度.
评估开发的生物墨的可打印性,学行为和生物相容性.

主要方法:

风湿学分析以确定粘弹性特性.
使用HEK293T细胞进行体外细胞毒性测试 (MTS测试).
使用商用生物打印机进行可打印性评估,其挤出条件不同.

主要成果:

确定了最佳度范围:≥2%KC,≥1.5%TG和1.5%-2%KG.
两种水凝配方 (A和B) 呈现出粘弹性和伪塑性行为.
配方B显示出高结构刚性和打印保真度 (>84%),而配方A显示出优异的生物相容性 (24小时内86.5%的细胞活力).

结论:

来自食物的多糖是生物墨水开发的有希望的,可持续的组成部分.
这种新的生物墨水配方为特定的组织工程需求提供了可调节的特性.
潜在的应用包括工程组织支架,体外模型和生物相容的3D打印系统.

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