电化学工程GQD用于选择性瘤向和三阴性乳腺癌的氧化纳米疗法
Mohammad Suhaan Dar1,2, Niroj Kumar Sahu1
1Centre for Nanotechnology Research, Vellore Institute of Technology (VIT), Vellore, Tamil Nadu 632014, India.
ACS omega
|January 26, 2026
概括
本研究介绍了一种绿色,快速的电化学方法,从石墨烯中创建石墨烯量子点 (GQD). 这些GQD显示选择性癌细胞杀死和安全的瘤成像在体内,为乳腺癌治疗提供了一个有前途的纳米平台.
科学领域:
- 纳米技术纳米技术
- 材料科学 材料科学 材料科学
- 生物医学工程 生物医学工程
背景情况:
- 石墨烯量子点 (GQD) 是生物医学应用的有希望的纳米材料.
- 传统的GQD合成方法可能是缓慢的,危险的,缺乏治疗意义.
- 开发可持续和高效的GQD生产对于临床翻译至关重要.
研究的目的:
- 为GQD合成开发一种快速,可持续和绿色的电化学方法.
- 描述合成的GQDs的物理化学特性.
- 为了评估体外和体内GQD的疗效和生物相容性三阴性乳腺癌 (TNBC) 治疗.
主要方法:
- 使用维生素C和氧化,对富含缺陷的石墨烯板进行电化学脱皮.
- 描述GQD的大小,光,分散性和表面功能.
- 在TNBC细胞和正常纤维细胞的体外细胞毒性测定.
- 在瘤携带小鼠的体内光成像和生物分布研究.
- 通过血液生物化学和组织病理学评估系统生物相容性.
主要成果:
- 合成的GQDs (3-10nm) 具有激发依赖的绿色光和高水性分散性.
- 通过产生活性氧物种 (ROS) 证明了对TNBC细胞的选择性体外细胞毒性.
- 在体内确认了优选瘤积累和脏清除.
- 展示了出色的系统生物相容性和治疗相关性.
结论:
- 开发的电化学方法为GQD生产提供了快速,安全和可持续的途径.
- 合成的GQD对TNBC表现出强大的超神能力.
- 这种绿色纳米平台在临床环境中具有显著的图像导向,ROS放大纳米异能体的潜力.
相关概念视频
What is an Electrochemical Gradient?
127.6K
Adenosine triphosphate, or ATP, is considered the primary energy source in cells. However, energy can also be stored in the electrochemical gradient of an ion across the plasma membrane, which is determined by two factors: its chemical and electrical gradients.
The chemical gradient relies on differences in the abundance of a substance on the outside versus the inside of a cell and flows from areas of high to low ion concentration. In contrast, the electrical gradient revolves around an...
The chemical gradient relies on differences in the abundance of a substance on the outside versus the inside of a cell and flows from areas of high to low ion concentration. In contrast, the electrical gradient revolves around an...
127.6K
Targeted Cancer Therapies
8.9K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
8.9K
Oxidation Numbers
42.5K
In redox reactions, the transfer of electrons occurs between reacting species. Electron transfer is described by a hypothetical number called the oxidation number (or oxidation state). It represents the effective charge of an atom or element, which is assigned using a set of rules.
42.5K
Oxidation-Reduction Reactions
75.5K
Oxidation–Reduction Reactions
75.5K
Cancer Stem Cells and Tumor Maintenance
6.0K
Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
6.0K
Scalar and Vector Triple Products
4.4K
Two vectors can be multiplied using a scalar product or a vector product. The resultant of a scalar product is scalar, while with vector products, the resultant is a vector. These rules of the scalar or vector product between two vectors can be applied to multiple vectors to obtain meaningful combinations. The scalar triple product is the dot product of a vector with the cross product of two vectors.
The scalar triple product is the dot product of a vector with the cross product of two vectors....
The scalar triple product is the dot product of a vector with the cross product of two vectors....
4.4K


