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甲状腺功能障碍与肝衰竭患者的预后之间的关联:系统性审查和元分析

Shaoyin Bao¹, Yin Pan², Yanyun Ruan¹

¹Precision Medicine Center, Taizhou Central Hospital (Taizhou University Hospital), Taizhou, China.

Frontiers in endocrinology

|January 26, 2026

概括

甲状腺功能障碍,特别是低FT3水平,显著增加肝衰竭患者的死亡风险. 常规的甲状腺功能测试可以帮助识别那些有更高风险的人,指导潜在的干预措施.

科学领域:

内分泌学在内分泌学.
肝病学肝病学是一种肝病学.
内部医学内部医学

背景情况:

肝衰竭在患者管理中提出了复杂的挑战.
甲状腺功能障碍是重症患者常见的并发症.
甲状腺功能障碍在肝衰竭的预后影响仍然不完全理解.

研究的目的:

系统地评估甲状腺功能障碍与肝衰竭成年患者的预后之间的关联.
评估甲状腺激素 (TSH,FT3,FT4) 对死亡率和其他不良结果的影响.
通过甲状腺功能评估来识别高风险患者群体.

主要方法:

在主要数据库 (PubMed,Embase,WOS,CNKI) 进行系统的文献搜索,直到2025年8月.
包括前性和后性研究来评估甲状腺功能和肝衰竭的结果.
聚合相对风险 (RRs) 的元分析,使用95%的置信区间 (CI);使用纽卡斯尔-太华尺度 (NOS) 进行质量评估.

主要成果:

分析了11项涉及3595名患者的研究.
甲状腺功能障碍与肝衰竭死亡率的增加有显著联系 (RR = 3.56).
低FT3水平显示了生存和死亡组之间的显著差异,表明预后较差.

结论:

甲状腺功能障碍,特别是低FT3,是肝衰竭死亡率的重要预测因素.
常规的甲状腺功能评估可能有助于识别高风险肝衰竭患者.
需要进一步的研究来阐明机制和治疗策略.

关键词:

自由的三甲氨酸.肝功能衰竭肝功能衰竭肝功能衰竭这是一个元分析.死亡率死亡率甲状腺功能障碍甲状腺功能障碍

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