子宫内膜厚度是否与子宫内授精中的生育结果有关? 一个队列研究
Tong Du1, Wentao Li2, Suqun Zhang1
1Department of Assisted Reproduction, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Frontiers in endocrinology
|January 26, 2026
概括
子宫内膜厚度 (EMT) 预测了子宫内授精 (IUI) 周期中的活产率. 较厚的子宫内膜与更高的成功相关,而较薄的子宫内膜减少了IUI的结果.
科学领域:
- 生殖医学 生殖医学
- 不孕症治疗 不孕症治疗
- 临床胚胎学 临床胚胎学
背景情况:
- 宫内授精 (IUI) 是对不明原因或男性因子不育的主要治疗方法.
- 子宫内膜厚度 (EMT) 对于预测IVF怀孕至关重要,但其在IUI成功中的作用仍在争论中.
- 现有的研究往往显示EMT和IUI成功之间没有关联,限制了其临床应用.
研究的目的:
- 调查子宫内胚胎厚度 (EMT) 对子宫内授精 (IUI) 周期中活产率的预测值.
- 为了澄清EMT在预测IUI成功方面的有争议的作用.
- 评估EMT作为优化IUI治疗结果的潜在标志物.
主要方法:
- 在一个单一中心对13,103个IUI周期 (2007-2021) 的回顾性队列研究.
- 将EMT分为薄 (<7毫米),中等 (7-14毫米) 和厚 (>14毫米) 的类别.
- 使用通用估计方程回归模型和反向倾向得分权重回归调整模型进行统计分析,包括非线性关系的限制立方线.
主要成果:
- 活产率与EMT有显著的差异:11.0% (薄),13.5% (中等) 和16.9% (厚).
- 薄型EMT与降低活产率有关 (aOR 0.82;95% CI 0.67-0.998),而厚型EMT显示出更高的比率 (aOR 1.22;95% CI 1.02-1.45).
- 对第一次IUI周期和受限立方脊柱模拟的分析证实了增加的EMT和活产率之间的线性,积极的关联.
结论:
- 触发日内的子宫内膜厚度是自然,莱特醇或淋巴激素刺激的IUI周期中活产的重要预测因素.
- 薄的子宫内膜厚度与IUI的成功率下降有关.
- EMT测量可以成为预测和潜在地改善IUI治疗结果的宝贵工具.
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