相关实验视频
Updated: Jan 27, 2026

09:18
A Gut-on-a-Chip Model to Study the Gut Microbiome-Nervous System Axis
Published on: July 28, 2023
3.5K
牛皮前后肠道微生物组的改变 用secukinumab治疗
Ling Fang1, Shasha Cheng1, Cheng Zuo2
1From the Department of Dermatology, Xishan People's Hospital of Wuxi City, Wuxi Branch of Zhongda Hospital Southeast University, Wuxi, Jiangsu, China.
Indian journal of dermatology
|January 26, 2026
概括
塞库金努马布有效治疗中度至重度的斑块性牛皮,改善临床症状并改变肠道微生物群的组成. 这些肠道微生物组的变化,包括特定细菌的变化,可能在牛皮病原和治疗反应中发挥作用.
科学领域:
- 免疫皮肤学 免疫皮肤学
- 微生物组研究 微生物组研究
- 胃肠病学 胃肠病学
背景情况:
- 牛皮是一种慢性炎症性皮肤疾病,其起源不清楚.
- 了解免疫系统的作用对于牛皮管理至关重要.
- 塞库金纽马布是适度至严重斑块性牛皮的已知治疗方法.
研究的目的:
- 评估Secukinumab在斑块性牛皮患者的疗效和安全性.
- 为了研究Seukinumab对肠道微生物群的影响.
- 为了将临床结果与微生物组变化相关联.
主要方法:
- 招募了110名牛皮病患者和60名健康对照.
- 收集的临床数据和便样本.
- 利用PacBio全长多样性测序来进行微生物分析.
主要成果:
- 在24周后,secukinumab显著降低了PASI,PGA,DLQI,Itch NRS和STAI分数.
- 肠道微生物的多样性和组成在治疗后发生了显著的变化.
- 观察到Agathobacter和Anaerobutyricum的丰度增加,Bacteroides和Phocaeicola的数量减少.
结论:
- 塞库金纽马布在治疗中度至重度斑块性牛皮方面表现出有效性.
- 在治疗Secukinumab时,肠道微生物群组成发生了显著的改变.
- 基于微生物组的研究对于了解牛皮和治疗反应很重要.
更多相关视频
相关概念视频
Alterations in Respiration II
1.7K
There are numerous types of normal and abnormal respiration. Based on ventilatory movements, breathing patterns are classified as regular, deep, or shallow. Examples include Biot's breathing, Cheyne-Stokes respiration, Kussmaul's breathing, hyperventilation, and hypoventilation. Each pattern is clinically significant and aids in evaluating patients.
In Biot's breathing, the respiratory rate and depth are irregular, alternating between periods of deep gasping and apnea. Common causes...
In Biot's breathing, the respiratory rate and depth are irregular, alternating between periods of deep gasping and apnea. Common causes...
1.7K
Altered States of Awareness
1.0K
Altered states of consciousness represent significant deviations from one's normal mental state. These deviations can range from subtle changes in awareness to profound transformations in perception, thought processes, and sensory experiences. Altered states of consciousness can be triggered by various factors, including drug use, meditation, hypnosis, illness, or even intense fatigue.
The ingestion of substances like stimulants or hallucinogens leads to chemical alterations in the brain...
The ingestion of substances like stimulants or hallucinogens leads to chemical alterations in the brain...
1.0K
Alterations in Blood Pressure
2.1K
Alterations in blood pressure, such as hypertension (high blood pressure) and hypotension (low blood pressure), significantly affect human health. Understanding these conditions' classifications, causes, and symptoms is essential for effective management and treatment.
Hypertension (High blood pressure)
Hypertension occurs when blood pressure readings consistently exceed the normal range. It is diagnosed when systolic blood pressure (the top number, indicating pressure while the heart...
Hypertension (High blood pressure)
Hypertension occurs when blood pressure readings consistently exceed the normal range. It is diagnosed when systolic blood pressure (the top number, indicating pressure while the heart...
2.1K
Physiology of Enteric Nervous System and Gut Health
915
The gastrointestinal tract, responsible for the digestion and absorption of nutrients, is safeguarded by the intestinal barrier, which consists of secretory, physical, and immune components. At the forefront is the secretory barrier, composed of essential elements such as mucus, gut microbiota, and defense proteins. They collaborate to break down food particles, facilitate nutrient absorption, and maintain optimal gut health. These secretory components ensure the smooth functioning of the...
915
Treating Helicobacter pylori in Peptic Ulcers: Antimicrobial Therapy
1.2K
Helicobacter pylori, a resilient gram-negative bacterium, can thrive in the stomach's harsh, acidic environment. Infection with H. pylori leads to a cascade of events within the stomach lining. One of the critical disruptions caused by this bacterium is the interference with somatostatin production, a hormone responsible for regulating acid secretion. This interference tips the balance, escalating acid secretion and diminishing bicarbonate levels. This imbalance compromises the defensive...
1.2K
Ribosomes
75.2K
Ribosomes translate genetic information encoded by messenger RNA (mRNA) into proteins. Both prokaryotic and eukaryotic cells have ribosomes. Cells that synthesize large quantities of protein—such as secretory cells in the human pancreas—can contain millions of ribosomes.
Ribosome Structure and Assembly
Ribosomes are composed of ribosomal RNA (rRNA) and proteins. In eukaryotes, rRNA is transcribed from genes in the nucleolus—a part of the nucleus that specializes in ribosome...
Ribosome Structure and Assembly
Ribosomes are composed of ribosomal RNA (rRNA) and proteins. In eukaryotes, rRNA is transcribed from genes in the nucleolus—a part of the nucleus that specializes in ribosome...
75.2K

