超细粒状失角化 - 阿尔巴变种
C K SriRam1, A S Krishnaram1, I Shibani1
1From the Department of Dermatology, Venereology and Leprosy, Velammal Medical College, Madurai, Tamil Nadu, India.
Indian journal of dermatology
|January 26, 2026
概括
超细粒状角膜异位 (HGD) 是一种罕见的皮肤病,通过组织学诊断. 这一案例突出显示,HGD呈现出不寻常的色素丧失,这一发现在医学文献中以前没有被记录.
科学领域:
- 皮肤病理学 皮肤病理学
- 组织病理学 组织病理学
- 在瘤学瘤学.
背景情况:
- 超细粒细胞失角化 (hypergranulotic dyscornification,简称HGD) 是一种通过异常的角质细胞成熟而表现出的组织病理反应模式.
- HGD缺乏特定的临床表现,因此组织学检查对于诊断至关重要.
- 该病症的罕见性和各种表现需要进一步报告病例.
研究的目的:
- 报告一个69岁的男性患者罕见的HGD病例.
- 调查与HGD相关的脱色的根本原因.
- 在这个独特的介绍中记录了他的病理学和免疫组织化学发现.
主要方法:
- 一个患有无症状色素脱落斑块和结节的患者的临床表现分析.
- 皮肤病变的组织病理学检查,以确定HGD特征.
- 特殊染色剂 (Fontana Masson) 和免疫组织化学 (HMB-45) 用于评估黑色素细胞的存在.
主要成果:
- 组织病理学证实了HGD,排除了诸如疹或斑疹角质炎之类的临时诊断.
- 丰塔纳·马森染色剂和HMB-45免疫组织化学检测显示,受伤皮肤中的黑色素细胞有显著的损失.
- 观察到的色素丧失与受影响区域的黑色素细胞损失直接相关.
结论:
- 这种病例代表了一种罕见的HGD呈现,由于黑色素细胞损失而导致的相关色素丧失.
- 这些发现扩大了对HGD潜在临床谱的理解.
- 需要进一步的研究来探索HGD,HGD Albicans和白风之间的潜在联系.
相关概念视频
Histone Variants at the Centromere
5.0K
Histone variants are the histone proteins with structural and sequence variations. These variants may be regarded as “mutant” forms that replace their canonical histone counterparts in the nucleosomes. Specific post-translational modifications on the histone variants enable further chromatin complexity and regulate tissue-specific gene expression. The most common histone variants are from histone H2A, H2B, and linker histone H1 families. However, several variants of histone H3...
5.0K
Gene Flow
37.7K
Gene flow is the transfer of genes among populations, resulting from either the dispersal of gametes or from the migration of individuals.
37.7K
Protein Complexes with Interchangeable Parts
2.9K
Groups of proteins may form a complex where each protein in this complex has a different role in the overall execution of the complex’s function. Often some of the proteins in the complex can be replaced by a closely related variant to give a complex that contains many of the same components yet is functionally distinct.
The SCF ubiquitin ligase is a protein complex of five individual proteins. This complex attaches ubiquitin to other target proteins to mark them for degradation. In order...
The SCF ubiquitin ligase is a protein complex of five individual proteins. This complex attaches ubiquitin to other target proteins to mark them for degradation. In order...
2.9K
Histone Modification
16.1K
The histone proteins have a flexible N-terminal tail extending out from the nucleosome. These histone tails are often subjected to post-translational modifications such as acetylation, methylation, phosphorylation, and ubiquitination. Particular combinations of these modifications form “histone codes” that influence the chromatin folding and tissue-specific gene expression.
Acetylation
The enzyme histone acetyltransferase adds acetyl group to the histones. Another enzyme, histone...
Acetylation
The enzyme histone acetyltransferase adds acetyl group to the histones. Another enzyme, histone...
16.1K
Epistasis
50.1K
In addition to multiple alleles at the same locus influencing traits, numerous genes or alleles at different locations may interact and influence phenotypes in a phenomenon called epistasis. For example, rabbit fur can be black or brown depending on whether the animal is homozygous dominant or heterozygous at a TYRP1 locus. However, if the rabbit is also homozygous recessive at a locus on the tyrosinase gene (TYR), it will have an unshaded coat that appears white, regardless of its TYRP1...
50.1K
Photoreceptors and Plant Responses to Light
28.4K
Light plays a significant role in regulating the growth and development of plants. In addition to providing energy for photosynthesis, light provides other important cues to regulate a range of developmental and physiological responses in plants.
28.4K


