案例报告:由弗蒙尼蒂尼布诱导的急性间歇性肺病
Yong-Liang Niu1, Ying Yang2, Jing-Feng Shi1
1Department of Respiratory and Critical Care Medicine, No. 2 People's Hospital of Fuyang City, Fuyang, China.
Frontiers in pharmacology
|January 26, 2026
概括
弗蒙尼提尼布是一种EGFR-TKI,尽管具有一般的安全性,但可以引起间歇性肺病 (ILD). 早期诊断和干预对于在肺腺癌患者中管理这种不良事件至关重要.
科学领域:
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
- 肺部病理学 肺部病理学
背景情况:
- 弗蒙尼蒂尼布是一种第三代不可逆转的表皮生长因子受体氨酸激酶抑制剂 (EGFR-TKI),用于EGFR突变肺腺癌 (LUAD).
- 虽然一般耐受性很好,但以前没有报告过与药物相关的严重间歇性肺病 (ILD).
研究的目的:
- 报告一种罕见的furmonertinib诱导的间歇性肺病 (ILD) 病例.
- 强调早期识别和管理这种不良事件的重要性.
主要方法:
- 一名71岁的妇女的病例报告,患有EGFR突变的LUAD,接受了furmonertinib治疗.
- 临床评估,排除间歇性肺炎的其他原因,并诊断与furmonertinib相关的ILD.
主要成果:
- 在furmonertinib治疗的第97天,患者出现了急性严重呼吸不全,扩散双侧肺结合和低氧化症.
- 在排除其他原因后,诊断出furmonertinib诱导的ILD.
- 患者通过及时诊断和干预,取得了良好的结果.
结论:
- 在EGFR突变肺腺癌的患者中,弗蒙尼提尼布可以诱导间歇性肺病 (ILD).
- 早期识别和及时管理对于扭转这种严重不良事件至关重要.
- 有效的管理可以为LUAD患者保留后续的治疗选择.
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