药物诱导的周围神经麻:基于FAERS数据的现实研究,从2004年到2024年第三季度
Yingjie Li1, Xueliang Yi2, Nengwei Yu1
1Department of Neurology, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.
Frontiers in pharmacology
|January 26, 2026
概括
这项研究使用FDA数据确定了与外围神经麻相关的高风险药物. 像纳塔利祖马布和布皮瓦卡因这样的药物显示风险增加,告知更安全的临床药物使用.
科学领域:
- 药监和药物安全 药监和药物安全
- 临床神经学 临床神经学
- 数据挖掘和健康信息学
背景情况:
- 周围神经麻显著影响患者的生活质量.
- 鉴定药物诱导的外周神经麻对于临床实践至关重要.
- 美国食品和药物管理局的不良事件报告系统 (FAERS) 是药物监测的关键数据来源.
研究的目的:
- 为了识别外围神经麻的不良药物反应信号.
- 在FAERS数据库中挖掘潜在的药物安全信号.
- 为提高临床药物使用的安全性提供基础.
主要方法:
- 从FAERS (2004-Q3 2024) 中提取了与外围神经麻相关的不良事件.
- 使用了四种药监测方法:ROR,PRR,MGPS和BCPNN.
- 分析了5,787份涉及1,141种药物的报告.
主要成果:
- 确定了30种具有外围神经麻的积极风险信号的药物.
- 纳塔利祖马布,干扰素β-1a和dalfampridine是报告病例最多的药物.
- 布皮瓦卡因,达尔法姆普里丁,纳塔利祖马布,米诺环素和奥克里祖马布被ROR和BCPNN标记为高风险.
结论:
- 几种药物,包括布皮瓦卡因,达尔法姆普里丁,纳塔利祖马布,米诺环素和奥克里祖马布,与外围神经麻风险有显著的关联.
- 这些发现有助于更好地理解药物安全性概况.
- 结果支持合理使用药物,并为临床决策提供信息.
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