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Updated: Jan 28, 2026

Polarization and Characterization of M1 and M2 Human Monocyte-Derived Macrophages on Implant Surfaces
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柏柏林通过阻断IL-4-JAK1-STAT6介导的巨细胞M2极化来抑制肝细胞癌的进展

Peng Wang1, Yuwen Zhong2,3,4, Mengkai Li2,3,4

  • 1Department of Hepatobiliary Medicine, Eastern Hepatobiliary Surgery Hospital, Shanghai, China.

Frontiers in pharmacology
|January 26, 2026
PubMed
概括

柏柏林 (BBR) 通过减少M2巨细胞两极分化来抑制肝癌 (HCC). 这种天然化合物向IL-4-JAK1-STAT6通路,增强CD8+T细胞活性,并可能与抗PD-L1疗法产生协同作用.

关键词:
在IL-4JAK1STAT6轴上巨细胞的M2极化柏柏林氨酸是一种柏柏林氨酸.肝细胞癌是肝细胞癌.瘤免疫的微环境

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