卵巢癌中使用新型抗瘤剂的间歇性肺病信号:一个三个数据库不成比例性研究
Chenguang Yang1, Xuan Song2, Hongmei Sun1
1Department of Gynaecology and Obstetrics, Affiliated Xuancheng Hospital of Wannan Medical College, Xuancheng, Anhui, China.
Frontiers in pharmacology
|January 26, 2026
概括
新型卵巢癌药物olaparib和mirvetuximab soravtansine-gynx显示了间歇性肺部疾病 (ILD) 的风险增加. 患者需要密切监测,以便早期检测和干预,以控制这种严重的副作用.
科学领域:
- 在瘤学瘤学.
- 药物监督 药物监督 药物监督
- 肺部病理学 肺部病理学
背景情况:
- 抗瘤药物可以引起间歇性肺病 (ILD),但实际数据有限.
- 卵巢癌治疗包括具有潜在ILD风险的新型抗瘤剂.
研究的目的:
- 为了识别与新型抗瘤剂与卵巢癌相关的ILD不成比例的报告信号.
- 为了分析与特定的卵巢癌药物相关的ILD信号的大规模不良事件数据库.
主要方法:
- 在FAERS,CVAR和JADER数据库 (2004-2025) 上使用贝叶斯不成比例分析.
- 包括FDA批准的用于卵巢癌的新型抗瘤剂.
- 计算了PRR,ROR和IC来检测ILD报告信号.
主要成果:
- 在FAERS中确定了olaparib,bevacizumab和mirvetuximab soravtansine-gynx的显著ILD信号.
- 在CVAR和JADER数据库中,Olaparib也显示了ILD信号.
- Mirvetuximab soravtansine-gynx具有最高的ILD相关死亡率 (29.41%).
结论:
- 与化疗相比,olaparib和mirvetuximab soravtansine-gynx与ILD的相关性更强.
- 接受这些药物的患者需要对ILD进行警监测.
- 早期的ILD检测和干预对于管理与治疗相关的肺部并发症至关重要.
相关概念视频
mTOR Signaling and Cancer Progression
4.7K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
The mTOR pathway or the...
4.7K
Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents
516
Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel...
516
Lung Capacity
56.2K
The air in the lungs is measured in volumes and capacities. Lung volume measures reflect the amount of air taken in, released, or left over after a lung function, like a single inhalation. Lung capacity measures are sums of two or more lung volume measures.
56.2K
Drugs for Peptic Ulcer Disease: Sucralfate as Mucosal Protective Agents
1.5K
In the intricate landscape of the gastric lumen, excessive acid secretion disrupts the natural defense mechanisms, weakening the mucus-bicarbonate barrier. This vulnerability allows pepsin to infiltrate epithelial cells, digesting mucosal proteins and triggering erosion, leading to ulcer formation.
In this scenario, mucosal protective agents like sucralfate play an essential role. Sucralfate, a complex of sulfated sucrose and aluminum hydroxide, demonstrates its usefulness in acidic conditions,...
In this scenario, mucosal protective agents like sucralfate play an essential role. Sucralfate, a complex of sulfated sucrose and aluminum hydroxide, demonstrates its usefulness in acidic conditions,...
1.5K
Drugs for Peptic Ulcer Disease: Prostaglandin Analogs as Mucosal Protective Agents
1.1K
The gastric mucosa produces prostaglandins E2 (PGE2) and prostacyclin (PGI2), crucial in maintaining gastric health. They exert cytoprotective effects, including increasing bicarbonate secretion, releasing protective mucin, reducing gastric acid output, and preventing harmful vasoconstriction. These effects are mediated through various receptors, such as EP1, EP2, EP3, and EP4.
Non-steroidal anti-inflammatory drugs (NSAIDs) can induce peptic ulcers by inhibiting cyclooxygenase, decreasing...
Non-steroidal anti-inflammatory drugs (NSAIDs) can induce peptic ulcers by inhibiting cyclooxygenase, decreasing...
1.1K
Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF
524
Tumor Necrosis Factor (TNF), a proinflammatory cytokine, contributes significantly to the inflammation seen in Crohn's disease. It exists as soluble TNF and membrane-bound TNF, with actions mediated through TNF receptors (TNFR). TNFR activation leads to the release of proinflammatory cytokines, T-cell activation, collagen production, and leukocyte migration, all contributing to inflammation in Crohn's disease. Anti-TNF monoclonal antibodies, namely infliximab (Remicade), adalimumab...
524


