,N-Dimethyl-p-toluidine:MAK价值文档 - 翻译2022年起的德语版本
1Institute of Applied Biosciences. Department of Food Chemistry and Toxicology. Karlsruhe Institute of Technology (KIT) Adenauerring 20a, Building 50.41 76131 Karlsruhe Germany.
概括
在动物研究中,N,N-二甲基-p-toluidine是一种致癌物 (类别2) 和致变物 (类别3B),会导致肝脏瘤和DNA损伤. 皮肤吸收是暴露的重要途径,需要采取处理预防措施.
科学领域:
- 毒理学 毒理学 毒理学
- 职业健康 职业健康 职业健康
- 化学安全 化学安全
背景情况:
- 德国委员会调查化学化合物在工作场所的健康危害 (MAK委员会) 评估了N,N-二甲基-p-toluidine.
- 职业暴露极限值 (MAK值) 对工作场所安全至关重要.
研究的目的:
- 为了评估N,N-二甲基-p-toluidine的毒理特征.
- 为了确定N,N-二甲基-p-toluidine的致癌性和致变性.
- 为了确定职业暴露限值.
主要方法:
- 在文献中搜索相关的毒理学研究.
- 对老鼠和大鼠的慢性输卵管研究的分析.
- 在体外和体外基因毒性测定.
- 皮肤吸收模型.
主要成果:
- 在小鼠和老鼠中,N,N-二甲基-p-toluidine诱导的肝腺瘤和肝癌.
- 在老鼠的鼻腔过渡性上皮,肺部和森林胃中也观察到瘤.
- 在体外观察到变异性,抗原性和克拉斯托基因性影响,在体内观察到DNA损伤.
- 通过皮肤吸收被确定为系统性毒性的重要途径.
结论:
- N,N-二甲基-p-toluidine被归类为致癌物类别2和生殖细胞致癌性类别3B.
- 该物质被标记为"H",因为它具有显著的皮肤吸收能力.
- 需要对生殖细胞突变性进行进一步的研究.
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