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甲基因组分析揭示了严重程度依赖的微生物继承和与宿主炎症反应的相关性,在口腔和面空间感染中
Xijun Wang1,2,3,4,5, Lei Ye1,2,3,4,5, Yimin Liu1,2,3,4,5
1Department of Oral Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Frontiers in cellular and infection microbiology
|January 26, 2026
概括
口腔和面空间感染 (OMSI) 显示出与严重程度相关的不同微生物群落. 一个特定的微生物特征,包括链球菌,与较高的炎症有关,这表明潜在的诊断标志物.
科学领域:
- 微生物学 微生物学
- 在口腔外科手术.
- 传染性疾病 传染性疾病
背景情况:
- 口腔和大面部空间感染 (OMSI) 存在,临床严重程度可变.
- 在OMSI中,瘤微生物群落与宿主炎症反应之间的相互作用尚未完全理解.
研究的目的:
- 研究OMSI腹中的微生物群体组成与不同感染严重程度的宿主炎症标志物之间的关系.
- 识别与不同严重程度的OMSI相关的潜在微生物特征.
主要方法:
- 对197名OMSI患者进行了回顾性,横截面的研究,分为轻度,中度和严重的群体.
- 腹的甲基因组下一代测序 (mNGS) 用于分析微生物群落.
- 系统性炎症标志物的评估和与微生物概况的相关性.
主要成果:
- 在OMSI重症组中观察到不同的微生物群落 (β-多样性),在轻度和重度感染之间有显著的转变.
- 严重的感染显示了Prevotella的丰富.
- 一个机器学习识别的微生物概况 (Streptococcus,Corynebacterium,Pseudomonas) 与系统性炎症标志物相相关,表明微生物异质性.
结论:
- 这项研究提供了探索性的见解菌群和宿主炎症在OMSI之间的关联.
- 研究结果强调了微生物群落的转变和与感染严重程度和全身炎症相关的特定类型.
- 需要进一步的前性研究来验证这些发现并探索它们的预测价值.
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