相关实验视频
Updated: Jan 27, 2026

12:02
Molecular Evolution of the Tre Recombinase
Published on: May 29, 2008
10.1K
在Desulfobacterota中,Wood-Ljungdahl路径和还原型甘氨酸路径的分子演变
Tomoyuki Wakashima1,2, Keitaro Kume3,4, Yoko Chiba1,5
1RIKEN Center for Sustainable Resource Science, Saitama, Japan.
Frontiers in microbiology
|January 26, 2026
概括
Desulfobacterota的共同祖先可能使用了Wood-Ljungdahl和还原型甘氨酸途径来固定碳. 随后的进化涉及基因丢失和水平基因转移,塑造了当前的代谢多样性.
科学领域:
- 微生物进化 微生物进化
- 生物化学 生物化学
- 基因组学就是基因组学.
背景情况:
- 碳固定对生态系统至关重要,但它的进化起源尚不清楚.
- 伍德-Ljungdahl (WL) 和还原型甘氨酸 (rGly) 路径是古老的碳固定路径.
- 脱硫细菌属成员使用WL或rGly途径进行自营生长.
研究的目的:
- 为了推断Desulfobacterota属内的WL和rGly路径的进化历史.
- 调查与这些碳固定通路相关的基因增加和损失事件.
- 为了了解Desulfobacterota的祖先的代谢能力.
主要方法:
- 在WL和rGly通路中对关键酶的基因存在/缺席分析.
- 参与碳固定的酶的遗传学分析.
- 完整基因组和下游生物合成基因的比较基因组学.
主要成果:
- 祖先的Desulfobacterota可能拥有WL和rGly通路的基因.
- 证据表明,祖先能够使用这些途径进行自营生长.
- 独立的基因丢失和水平基因转移事件塑造了后代血统中的进化途径.
结论:
- 脱硫菌的碳固定路径是通过垂直遗传,基因丢失和水平基因转移而演变的.
- 祖先的自营养能力通过进化过程得到了修改.
- 了解这些途径为微生物代谢和进化提供了洞察力.
相关概念视频
C4 Pathway and CAM
49.0K
Most plants use the C3 pathway for carbon fixation. However, some plants, such as sugar cane, corn, and cacti that grow in hot conditions, use alternative pathways to fix carbon and conserve energy loss due to photorespiration. Photorespiration is the process that occurs when the oxygen concentration is high. Under such conditions, the rubisco enzyme in the Calvin cycle binds O2 instead of CO2, which halts photosynthesis and consumes energy.
C4 Pathway
The C4 pathway is used by plants such as...
C4 Pathway
The C4 pathway is used by plants such as...
49.0K
Other Glycolytic Pathways
860
The pentose phosphate pathway (PPP) operates in parallel with glycolysis, facilitating the metabolism of both pentoses and glucose. This pathway consists of two distinct phases: the oxidative and non-oxidative phases. While it does not directly generate ATP, the intermediates formed during the process can integrate into glycolysis, contributing to cellular energy metabolism when required.Oxidative Phase: NADPH ProductionThe oxidative phase of the pentose phosphate pathway is primarily...
860
Respiration Pathways
725
Cellular respiration is a fundamental metabolic process that enables organisms to generate energy from organic molecules. One of its central pathways is the tricarboxylic acid (TCA) cycle, also known as the Krebs cycle, which plays a crucial role in energy production and biosynthetic processes.Conversion of Pyruvate to Acetyl-CoAThe pyruvate generated from glycolysis undergoes oxidative decarboxylation by the pyruvate dehydrogenase complex, producing acetyl-CoA, one molecule of NADH, and one...
725
Auditory Pathway
7.2K
Auditory pathways constitute the complex neural circuits responsible for transmitting and interpreting auditory information from the peripheral auditory system to the brain. Sound waves are initially captured by the outer ear, funneled through the ear canal, and reach the tympanic membrane (eardrum). These vibrations are transmitted via the middle ear's ossicles to the inner ear's cochlea.
When viewed cross-sectionally, the cochlea reveals the scala vestibuli and scala tympani flanking...
When viewed cross-sectionally, the cochlea reveals the scala vestibuli and scala tympani flanking...
7.2K
ER Retrieval Pathway
4.7K
In the secretory pathway, vesicles transport proteins from one cellular compartment to another in forward transport to deliver the protein to its correct location. Occasionally, misfolded proteins and incorrect proteins escape their original compartments, and a retrieval pathway is used to return the escaped proteins to their original compartment.
The ER uses many checkpoints to prevent the entry of incorrectly folded or a resident protein as cargo onto a transport vesicle. These mechanisms...
The ER uses many checkpoints to prevent the entry of incorrectly folded or a resident protein as cargo onto a transport vesicle. These mechanisms...
4.7K
Indirect Motor Pathways
3.2K
The indirect motor or extrapyramidal pathways originate in the brainstem, the lower portion of the brain that connects it to the spinal cord. They consist of several distinct tracts, each with specialized functions. The four main tracts of the indirect motor pathways are the vestibulospinal tract, the reticulospinal tract, the tectospinal tract, and the rubrospinal tract.
The vestibulospinal tract originates in the vestibular nuclei of the brainstem. The vestibular system detects changes in...
The vestibulospinal tract originates in the vestibular nuclei of the brainstem. The vestibular system detects changes in...
3.2K

