对拉萨梅拉斯马群体的皮肤生理参数和毛细菌群特征的调查 中国 中国
Longwei Fang1, Bu Luo2, Deqiong Danzen1
1High Altitude Health Science Research Center, Tibet University, Lhasa, China.
Frontiers in microbiology
|January 26, 2026
概括
在西藏的高海拔疹与特定的皮肤参数和真菌存在有关,特别是Aspergillus和Aureobasidium. 这些因素为预测和治疗这种色素障碍提供了潜力.
科学领域:
- 皮肤病学和微生物学
- 高海拔的生理学 高海拔的生理学
- 人类遗传学 人类遗传学
背景情况:
- 梅拉斯马呈现为对称的面部色素,受紫外线辐射,皮肤参数和微生物多样性的影响.
- 高海拔环境带来了独特的挑战,可能会改变诸如黑色素瘤等皮肤疾病.
研究的目的:
- 为了研究皮肤参数,微生物群和在高海拔地区遗传藏人中疹患病率之间的关系.
- 探索在高海拔地区的人群中发生疹的潜在机制.
主要方法:
- 涉及302名遗传西藏人的横截面研究,在西藏拉萨.
- 测量皮肤生理参数:皮肤皮脂 (SM),角膜水分含量 (CM),pH,皮肤间的水分损失 (TEWL),红斑指数 (E),黑色素 (M) 和个体类型角度 (ITA).
- 皮肤微生物组 (细菌和真菌) 的测序和分析以及与临床和生理数据的相关性.
主要成果:
- 梅拉斯马的患病率为11.92%,女性明显高 (16.67%),31-40岁女性 (37.50%) 达到峰值.
- 黑色素患者的pH值显著降低,黑色素 (M) 值更高.
- 菌属Aspergillus和Aureobasidium在黑色素瘤患者中更为丰富 (p <0.05) 并显示出预测值 (AUC 0.798-0.828).
- 在微生物群和皮肤参数 (ITA,TEWL,pH,E,M,SM) 之间发现了显著的相关性.
结论:
- 高海拔的西藏黑色素与独特的皮肤参数和微生物群概况有关.
- 真菌群体,特别是阿斯伯吉卢斯和奥雷奥巴西迪乌,在高海拔地区的瘤发育中发挥着作用.
- 微生物群的特征和皮肤参数为预测,预防和治疗高海拔群体中的疹提供了基础.
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