表面压缩在vivo中改变了人体乳房的VisR刚度,粘度和 anisotropy测量
Anna V Phillips1, Cherie M Kuzmiak2, Doreen Steed2
1Lampe Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill, North Carolina State University, Chapel Hill, NC 27514 USA.
概括
表面压缩显著影响粘弹性响应 (VisR) 超声波测量乳腺组织刚性和粘度,特别是在密集的乳房. 标准化压缩对于使用VisR成像来准确诊断乳腺癌至关重要.
科学领域:
- 生物医学超声波 生物医学超声波
- 医疗成像医学成像
- 生物物理学的生物物理.
背景情况:
- 粘弹性反应 (VisR) 超声波是一种非侵入性,低成本的成像技术,用于评估组织刚性和粘度.
- 在乳腺癌诊断方面,VisR显示出有前途的潜力,有可能改善乳房密度较高的乳房的检测,而乳房扫描效果较差.
- 初步研究表明,VisR可以根据度,粘度和异型性来区分恶性和良性乳腺病变.
研究的目的:
- 评估应用表面压缩对乳腺组织VisR测量的影响.
- 为了评估密集和不密集乳房的女性之间的压缩效应的差异.
- 为了确定压缩对峰值位移 (PD),相对弹性 (RE),相对粘度 (RV) 和异构度 (DoA) 的影响.
主要方法:
- 一个IRB批准的临床研究,涉及20名没有已知的乳腺病理的妇女.
- 在不同水平的表面压缩下,对PD,RE,RV和DoA进行了VisR测量.
- 参与者的乳房密度被分类,其中10/20具有乳房密度丰富的乳房.
主要成果:
- 表面压缩在体内显著影响了PD,RE和RV的测量.
- 压缩时,硬度 (PD和RE) 显著增加,特别是在乳房密集的女性中.
- 压缩对DoA的影响有所不同 (增加,减少或不变),乳腺密度组之间没有显著差异.
结论:
- 应用表面压缩是影响乳腺组织VisR测量的重要因素.
- 建议对临床VisR乳房成像进行压缩的标准化和监测,特别是对于乳房密度较高的女性.
- 需要进一步的研究来确定可重复的VisR测量最佳应变范围.
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