在畜牧工人中D型流感病毒的血清流行:职业健康视角
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Updated: Jan 28, 2026

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Generation of Recombinant Influenza Virus from Plasmid DNA
Published on: August 3, 2010
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Claudia Maria Trombetta1,2, Angela Stufano3, Valentina Biagini4
1Department of Molecular and Developmental Medicine, University of Siena, Siena, Italy.
Journal of medical virology
|January 26, 2026
概括
研究了意大利牛畜工人和对照组的D型流感病毒 (IDV) 暴露. 牛畜工人显示出显著的IDV血清流行率,表明职业动物感染风险.
科学领域:
- 兽医病毒学 兽医病毒学
- 动物传播疾病流行病学
- 公共卫生 公共卫生
背景情况:
- 2011年首次隔离的D型流感病毒 (IDV) 疑似以牛为其自然储备.
- IDV已经向各种动物宿主展示了溢出事件,引发了对潜在的动物传染病传播的担忧.
- 了解人类群体中IDV血清流行率对于评估公共卫生风险至关重要.
研究的目的:
- 在意大利南部的牛畜工人中调查两种IDV血统 (D/660和D/OK) 的血清流行.
- 评估与畜牧业职业相关的动物感染风险.
- 将牛畜工人中的IDV血清流行与来自同一地区的对照组进行比较.
主要方法:
- 血清样本从2023年至2024年期间在意大利南部的畜牧工人和对照组中收集.
- 血液凝结抑制和病毒中和 (VN) 试验用于检测针对IDV系D/660和D/OK的抗体.
- 进行了统计分析,以确定血清流行率,并比较职业群体之间的发现.
主要成果:
- 总体而言,42.9%的牛畜工人至少有一种IDV血统的阳性测试,其中39.3%为D/660阳性,34.3%为D/OK.
- 病毒中和 (VN) 试验证实了通过血液凝结抑制获得的几乎所有积极结果.
- 与畜牧工人相比,在对照组中观察到IDV系D/660的显著更高的血清流行率为65.0%,比牛工人高.
结论:
- 接触IDV不仅限于与牛有直接职业接触的个人.
- 这些发现表明,在一般人群中,IDV的流通范围比以前假设的更广泛.
- 加强流感监测计划应考虑将IDV纳入其中,以更好地监测其传播动态和潜在的公共卫生影响.
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