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相关概念视频

Residual Stresses01:26

Residual Stresses

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Residual stresses reside in a structure even after removing the original stress inducer. This phenomenon often arises from varied plastic deformations across different parts of a structure. Consider a rod stretched beyond its yield point. It will not regain its original length due to permanent deformation. Even after load removal, the rod does not entirely lose stress because of uneven plastic deformations, resulting in residual stresses. The computation of these stresses in structures is...
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Residual Plots01:07

Residual Plots

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A residual plot is a statistical representation of data used to analyze correlation and regression results. It helps verify the requirements for drawing specific conclusions about correlation and regression. To obtain the residual plot, first, the residual for each data value is calculated, which is simply the vertical distance between the observed and the predicted value obtained from the regression equation.
When the residual values are plotted against the variable x, it is called a residual...
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Finding the Center of Gravity01:03

Finding the Center of Gravity

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The center of gravity of a body is an imaginary point where the body's total weight is assumed to be concentrated, and the body is perfectly balanced. The center of the mass of a body is a point at which the whole of the mass of the body appears to be concentrated. If the acceleration due to gravity, g, has the same value at all points on a body, its center of gravity is identical to its center of mass. The center of gravity of homogeneous bodies such as a sphere, cube, or rectangular plate...
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Residual Stresses in Circular Shafts01:10

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In materials that exhibit elastic and plastic behavior, known as elastoplastic materials, residual stresses can accumulate when these materials experience plastic deformation. This deformation arises from either high levels of shearing stress or significant strains. Residual stresses are internal stresses that persist within a material after removing the external force causing deformation. This phenomenon is demonstrated when observing the behavior of a shaft under torque; notably, the...
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Respiratory System Abnormal Finding I: Inspection and Percussion01:30

Respiratory System Abnormal Finding I: Inspection and Percussion

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Respiratory system abnormalities are a significant concern in healthcare due to their potential to indicate underlying severe conditions like Chronic Obstructive Pulmonary Disease (COPD), asthma, and pneumonia. These abnormalities can often be detected through physical examination methods like inspection and percussion.
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Cardiovascular System Abnormal Findings I: Inspection and Palpation01:29

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In a cardiovascular examination, inspection and palpation are crucial for identifying abnormalities.
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在更少的时间里找到更多:使用残留细胞学样本治疗胰腺癌的精准医学.

Raquel Antón-Peñalver1, María Ortega2, Jose Francisco González-Muñoz2

  • 1Departament de Patologia, Facultat de Medicina i Odontologia, Universitat de València, València, Spain.

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胰腺管腺癌 (PDAC) 的剩余液体基细胞学 (LBC) 适用于分子分析,即使在长期储存后也是如此. 保存这些样本可以确保患者能够获得有针对性的治疗方法.

关键词:
细胞块的细胞块是什么?基于液体的细胞学.微卫星的不稳定性这是下一代测序.胰腺腺癌的癌症.

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科学领域:

  • 在瘤学瘤学.
  • 分子诊断学 分子诊断学
  • 胃肠病学 胃肠病学

背景情况:

  • 胰腺管腺癌 (PDAC) 是一种致命的恶性瘤,发病率越来越高.
  • 准确的诊断依赖于病理确认,通常是通过内镜超声波引导细针吸收 (EUS-FNA).
  • 剩余液体细胞学 (LBC) 样本用于PDAC分子测试的实用性尚未得到充分证实.

研究的目的:

  • 评估用于PDAC分子分析的剩余LBC样本的实用性和储存条件.
  • 为了确定剩余的LBC是否可以可靠地用于下一代测序 (NGS) 和其他分子测试.
  • 评估储存时间对从LBC样本中核酸质量的影响.

主要方法:

  • 从2020年至2024年通过EUS-FNA和LBC诊断的268名PDAC患者的回顾性分析.
  • 储存了剩余的LBC样本,并根据可用性和质量进行了分子分析.
  • 剩余LBC和细胞块之间的DNA和RNA质量和测试有效性的比较.

主要成果:

  • 剩余的LBC是8名患者唯一可用的样本.
  • 与细胞块相比,LBC中的DNA度更高,中位数绝对对对差 (MAPD) 较低.
  • 液体细胞储存时间没有影响NGS有效性,结果与DNA和MSIRT-PCR细胞块相比.
  • RNA分析产生了较少的有效研究,LBC和细胞块之间没有显著差异.

结论:

  • 来自PDAC的剩余LBC样本可用于分子分析,保持核酸质量.
  • 剩余的LBC可以作为分子测试的主要或唯一的样本.
  • 保存剩余的LBC对于确保患者获得必要的向疗法至关重要.