"C反应蛋白-白蛋白-淋巴细胞指数与胆结石疾病之间的关联:一个横截面研究"
Xingxing Liu1, Kang Li1, Yonghua Zeng1
1Department of Gastroenterology, Jiangxi Provincial Key Laboratory of Digestive Diseases, Jiangxi Clinical Research Center for Gastroenterology, Digestive Disease Hospital, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China.
Clinical and translational gastroenterology
|January 26, 2026
概括
新的C-反应蛋白-白蛋白-淋巴细胞 (CALLY) 指数显示,与胆结石风险存在显著的反向关联. 较高的CALLY指数值与较低的胆结石患病率相关,表明其早期检测的潜力.
科学领域:
- 生物标志物 生物标志物
- 胃肠病学 胃肠病学
- 公共卫生 公共卫生
背景情况:
- 胆结石对健康造成重大负担.
- 对于早期风险识别,需要新的生物标志物.
- 对C反应性蛋白-白蛋白-淋巴细胞 (CALLY) 指数是一个新的潜在指标.
研究的目的:
- 研究CALLY指数与胆结石风险之间的关联.
- 评估CALLY指数与其他炎症标志物的预测性能.
- 探索CALLY指数与胆结石关系中的潜在调解因素.
主要方法:
- 对NHANES数据 (2017-2020年) 的横截面分析.
- 多变量逻辑回归和受限立方线 (RCS) 用于关联和非线性.
- 进行了子组,调解 (Conicity,LAP,ABSI) 和ROC曲线分析.
主要成果:
- 最高的CALLY指数四分位数与明显较低的胆结石风险 (或0.56) 相关.
- RCS证实了CALLY指数和胆结石风险之间的线性反相关性.
- 与SII,SIRI和AISI相比,CALLY指数显示出更好的预测性能 (AUC=0.604).
结论:
- 在CALLY指数和胆结石患病率之间存在显著的反向关联.
- 卡利指数显示,它是早期胆结石风险评估的客观生物标志物.
- 圆度指数在这个协会中成为一个重要的调解者.
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