肌肉的生命周期形态轨迹:一个横截面高分辨率MRI研究
The Journal of craniofacial surgery
|January 26, 2026
概括
的肌肉 (MMTs) 在年轻时快速生长,在成年时稳定,在30岁后,其厚度下降,特别是在肌和肌肌中. 这些MMT变化提供了对衰老的见解.
科学领域:
- 人体解剖学 解剖学 解剖学
- 生物医学工程 生物医学工程
- 放射学 放射学是一门学科.
背景情况:
- 的肌肉 (MMTs) 对于下功能至关重要.
- MMT正在成为与年龄相关疾病的潜在生物标志物.
- 对于MMTs,存在有限的寿命形态数据,特别是在肌之外.
研究的目的:
- 描述MMT在人类一生中的发展轨迹.
- 评估MMT双边对称性,性别差异和比较形态.
- 提供MMTs作为临床生物标志物的参考数据.
主要方法:
- 在211名受试者 (年龄为1-87岁) 上使用了高分辨率3.0TMRI.
- 四个MMT的形态测量测量 (长度,宽度,厚度) 是双边进行的.
- 洛斯回归和布兰德-阿尔特曼分析评估了与年龄相关的趋势和对称性.
主要成果:
- 在儿童/青少年时期,MMTs呈现出快速增长,在25-30岁时达到顶峰.
- 成年肌肉的长度和宽度是稳定的;厚度在30岁后逐渐下降,在60岁后加速.
- 观察到高的双边对称性;性二态性在青春期出现.
结论:
- MMT形态表现出不同的寿命轨迹,厚度是最敏感的参数.
- 体和体肌肉显示了与年龄相关的显著厚度下降,与体肌肉不同.
- 结果支持MMT测量作为临床生物标志物,建议考虑超出骨厚度的参数.
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