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STARTER:基于模块化和开放设计原则的独立可重新配置和翻译器官芯片平台

Aniruddha Paul¹, Eric R Safai², Laura E de Heus²

¹BIOS Lab on Chip Group, Mesa+ Institute of Nanotechnology, University of Twente, The Netherlands.

|January 26, 2026

概括

一个新的模块化微流体平台 (OoC) 将器官芯片系统标准化用于药物测试. 这种开源设计促进了互操作性和协作,加速了器官芯片技术的采用.

科学领域:

生物技术是生物技术.
微流体学微流体学
药物发现药物发现药物发现

背景情况:

器官芯片 (OoC) 为药物测试提供了革命性的潜力,但由于系统碎片化而面临采用障碍.
需要标准化,可互操作的平台来整合各种OOC模型和组件,促进协作和资源效率.

研究的目的:

引入一个模块化,开源的微流体平台,旨在无集成和标准化器官芯片系统.
在芯片器官生态系统中实现互操作性和模块化,促进OOC技术的更广泛采用和翻译.

主要方法:

开发一个模块化微流体平台,在ANSI/SLAS微板足迹中集成可交换的送,传感和OOC模块.
使用微流体构建块 (MFBB) 和流体电路板 (FCB),遵循ISO标准,用于无管,可重新配置的流体互连.
使用体外和体外OoC模型在多天内使用集成传感器证明生物功能.

主要成果:

成功实施了一个模块化微流体平台,使无管,可重新配置的流体电路用于器官芯片系统.
在平台中长期集成的体外和体外器官芯片模型的已证明的生物功能.
验证平台对自动化多器官实验的能力,无论器官芯片类型或材料如何.

结论:

开发的模块化微流体平台提供了一个标准化,开源的解决方案,以克服器官芯片技术的碎片化.
这种方法提高了互操作性,促进了合作,并支持自动化的多器官实验,为加速药物发现铺平了道路.
该平台的开源性质鼓励在器官芯片领域广泛采用和进一步创新.

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