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Updated: Jan 27, 2026

External Cephalic Version: Is it an Effective and Safe Procedure?
Published on: June 6, 2020
纳夫他林:MAK价值文档,附录 - 翻译2022年起的德语版本
1Institute of Applied Biosciences. Department of Food Chemistry and Toxicology. Karlsruhe Institute of Technology (KIT) Adenauerring 20a, Building 50.41 76131 Karlsruhe Germany.
纳夫他林暴露会在动物中引起癌症,但人类数据缺乏. 由于不确定性,它仍然被归类为潜在的致癌物和生殖细胞变异原体,并指出皮肤吸收.
科学领域:
- 毒理学 毒理学 毒理学
- 职业健康 职业健康 职业健康
- 化学安全 化学安全
背景情况:
- 马克委员会重新评估了纳的毒理学数据.
- 以前的评估考虑了各种毒理终点.
研究的目的:
- 总结和重新评估现有关于甲健康危害的数据.
- 为了确定纳夫他林在致癌性和致变性方面的分类.
主要方法:
- 对相关的毒理学研究进行全面的文献搜索.
- 对动物 (老鼠和小鼠) 的致癌性研究的分析.
- 突变性数据的评估 (体外和体内).
主要成果:
- 纳弗他林的吸入导致了老鼠的鼻瘤和小鼠的肺瘤.
- 纳夫他在体外没有变异性,但体内数据有限.
- 致癌性可能源于一种非遗传毒性机制,包括高剂量的炎症和细胞增殖,尽管不能完全排除遗传毒性机制.
- 没有发现人体效应值.
- 纳夫他林通过皮肤被吸收.
结论:
- 纳夫他林仍然被归类为致癌物类别2和生殖细胞致癌物类别3B.
- 需要进一步的研究来澄清基因毒性潜力,并确定人类效应值.
- 标记"H"表示有毒学意义的皮肤吸收.
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