相关实验视频
Updated: Jan 28, 2026

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External Cephalic Version: Is it an Effective and Safe Procedure?
Published on: June 6, 2020
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三二 (所有异构体):MAK价值文档,附录 - 翻译2022年起的德语版本
1Institute of Applied Biosciences. Department of Food Chemistry and Toxicology. Karlsruhe Institute of Technology (KIT) Adenauerring 20a, Building 50.41 76131 Karlsruhe Germany.
概括
马克委员会根据肝脏和脏的毒性,特别是大鼠的毒性,为三化设定了新的职业暴露限值0.5毫升/立方米. 这些化合物对人类没有遗传毒性或致癌性.
科学领域:
- 职业健康 职业健康 职业健康
- 毒理学 毒理学 毒理学
- 环境化学环境化学
背景情况:
- 三二异构体可能带来职业健康风险.
- 以前的职业暴露极限值 (MAK值) 需要根据最新的毒理数据重新评估.
研究的目的:
- 重新评估三二同体 (1,2,3-, 1,2,4-,和 1,3,5-三二) 的MAK值.
- 评估所有毒理终点,包括对肝脏,脏,发育和敏感性的影响.
主要方法:
- 综合的文献搜索和未发表的研究报告的审查.
- 来自动物研究 (老鼠和大鼠) 的毒理学数据的评估.
- 确定关键效应和敏感物种,以确定暴露限值.
主要成果:
- 关键效应是小鼠/大鼠的肝毒性和大鼠的毒性,其中1,2,4-三二是最有效的.
- 在大鼠中,氨酸生物合成中断的NOAEC为3毫升/米3,导致新的MAK值为0.5毫升/米3.
- 三烯不具有基因毒性;观察到的瘤与人类无关. 发育和产周毒性数据支持怀孕风险组C分类.
结论:
- 三二同位素的MAK值设置为0.5毫升/立方米,峰值限制类别为II.
- 1,2,3-三二为皮肤敏感化被指定为"Sh";所有异构体被指定为"H"用于皮肤吸收.
- 马克委员会的调查结果为工作场所安全提供了关键的指导,涉及三二暴露.
关键词:
1,2,3-三二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二1,2,4-三二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二1,3,5-三二二二烯的使用方法这就是MAK值的MAK值.致癌性 致癌性 致癌性在工作场所的最大度.代谢 代谢 代谢 代谢突变性 突变性 突变性甲酸氨酸尿症是什么?毒性的毒性 毒性的毒性相关概念视频
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