青少年患有异常隔离GHD的HRQoL:在青春期中期的rhGH (失效) 延续
Joeri Vliegenthart1, Jan Busschbach2, Edmond H H M Rings3
1Division of Paediatric Endocrinology, Department of Paediatrics, Erasmus University Medical Centre, Sophia Children's Hospital, Rotterdam, the Netherlands.
Endocrine connections
|January 26, 2026
概括
在具有足够GH的异常分离生长激素缺乏症 (IIGHD) 的青少年中停止复合人体生长激素 (rhGH) 治疗不会对他们的生活质量产生负面影响. 父母报告表明,当治疗停止时,幸福感有所改善.
科学领域:
- 儿科内分泌学 儿科内分泌学
- 生活质量研究 研究 生命质量研究
- 青少年健康 青少年健康
背景情况:
- 异常分离生长激素缺乏症 (IIGHD) 通常需要长期使用复合人体生长激素 (rhGH) 治疗.
- 对于GH充足的青少年来说,关于在青春期中期停止使用rhGH的治疗决定是复杂的,可能会对生活质量 (QoL) 有影响.
- 身高和外表是影响青少年心理社会发展和生活质量的重要因素.
研究的目的:
- 评估IIGHD青少年的与健康相关的生活质量 (HRQoL),这些青少年的GH检测足够.
- 为了比较那些在青春期中断了rhGH的人与那些继续直到接近成年人身高 (NAH) 的人之间的HRQoL.
主要方法:
- 一项多中心前性患者偏好研究,涉及IIGHD的青少年.
- 参与者在青春期中期测试GH充足后选择继续或停止rhGH治疗.
- 在青春期中期和NAH时使用QoLISSY,KIDSCREEN-52,SDQ和EQ-5D-Y评估HRQoL.
主要成果:
- 在青春期中期或NAH的组之间没有发现患者报告的HRQoL的显著差异.
- 父母报告说,在中期青春期停止服用rhGH的组中,QOL更高.
- 总体QOL得分保持在正常范围内,与身高SDS正相关.
结论:
- 在IIGHD的GH不足青少年中停止服用rhGH不会对感知HRQoL产生负面影响.
- 家长报告表明,在停止治疗后,健康状况可能有所改善.
- 治疗决策应整合身体和心理社会因素,考虑患者和家长的观点.
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