铁平衡与酒精消费和肝硬化/纤维化之间的关联:多队列分析
Xin Zhang1, Haili Wang1, Chengnan Guo1
1.Department of Epidemiology, School of Public Health, Key Laboratory of Public Health Safety, Fudan University, Shanghai, China.
The Journal of endocrinology
|January 26, 2026
概括
酒精摄入量,尤其是中度摄入量,与增加肝脏脂肪和纤维化风险有关. 铁代谢中断部分解释了这种与酒精有关的肝损伤,建议对铁进行预防监测.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 营养科学 营养科学
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 酒精消费与肝硬化/纤维化之间的联系仍在争论中,特别是在低至中等摄入量水平时.
- 铁平衡障碍在饮酒者中很常见,可能导致肝损伤.
研究的目的:
- 调查改变的铁代谢是否调解了酒精摄入量和肝损伤之间的关联.
- 为了检查酒精消费与肝脏脂肪和纤维化之间的关系.
主要方法:
- 国家健康和营养检查调查 (NHANES) 和英国生物库数据的分析.
- 采用了多变量物流,Cox比例危险,受限立方线 (RCS) 和门德尔随机化 (MR) 分析.
- 调解分析评估了铁生物标志物在与酒精有关的肝损伤中的作用.
主要成果:
- 在酒精摄入量和肝脂肪 (PDFF) 之间发现了J形关联,低摄入量反向和中度至重量摄入量正相关.
- 较高的酒精消费与发生肥胖症和纤维化症的风险增加有关.
- 铁的稳态生物标志物,特别是肝脏的铁,部分介导了酒精摄入量和肝损伤之间的关系.
结论:
- 酒精消费与肝脏脂肪和纤维化风险的增加有关,部分原因是铁平衡受损.
- 这些发现表明,监测暴露于酒精的人的铁代谢可能有助于预防与酒精有关的肝病进展.
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