多发性骨髓瘤患者第一个和随后的骨折的发生率:使用英国CPRD数据集进行并行队列研究
Rohit Vijjhalwar1, Kaiyang Song2, Franz Clemeno3
1University Hospital Southampton NHS Foundation Trust, Southampton, UK.
概括
多发性骨髓瘤 (MM) 患者在诊断前的骨折风险较高,诊断后的脊椎骨折风险增加. 早期发现MM和减少骨折风险至关重要.
科学领域:
- 整形外科 整形外科 整形外科
- 血液学 血液学 血液学
- 流行病学 流行病学
背景情况:
- 众所周知,多发性骨髓瘤 (MM) 会增加骨折的风险.
- 在MM患者中,随后骨折的发生率和特征需要进一步阐明.
研究的目的:
- 在MM患者的真实世界队列中量化索引和随后骨折的发生率.
- 将MM患者的骨折发生率与匹配的非MM对照进行比较.
主要方法:
- 使用了英国临床实践研究数据链接GOLD (1995-2017).
- 确定了MM队列和年龄,性别,GP实践匹配的对照.
- 分析了2年内主要骨质疏松部位的骨折,预/后MM诊断,使用考克斯模型估计了随后骨折的累积发病率.
主要成果:
- 与对照组相比,MM患者的指数骨折率在诊断前1年开始显著增加.
- 随后的两年内,主要骨折率与MM相似 (14.7%MM与14.6%非MM).
- 毫米瘤患者在2年后的指数骨折 (aHR:8.16) 中,随后的脊椎骨折的风险显著增加.
结论:
- 多发性骨髓瘤患者在诊断前面临指数骨折风险升高和诊断后增加后续脊椎骨折风险.
- 研究结果表明,在患有重大骨折的成年人中,可能会更早地诊断出MM.
- 实施降低MM患者后续骨折风险的策略至关重要.
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