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专利孔圆形关闭中风和帕斯卡分类系统.

Jeffrey L Saver1,2, David M Kent3, Scott E Kasner4

  • 1Comprehensive Stroke Center, David Geffen School of Medicine, University of California, Los Angeles.

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概括

帕斯卡分类系统有助于识别患有形孔 (PFO) 的患者,他们可以从PFO关闭中受益,以防止中风的复发. 它准确地预测大多数患者的净益处,同时识别那些可能遭受伤害的人.

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科学领域:

  • 心血管医学 心血管医学
  • 神经学 神经学
  • 医学诊断 医学诊断 医学诊断

背景情况:

  • 专利卵孔 (PFO) 的关闭减少了中风的复发,但增加了心房动 (AF) 的风险.
  • 为PFO关闭进行最佳患者选择至关重要,以最大限度地提高益处并最大限度地减少伤害.

研究的目的:

  • 评估PFO相关的中风致病概率 (PASCAL) 分类系统.
  • 为了确定帕斯卡是否准确地识别了从PFO关闭中获得净利益的患者.

主要方法:

  • 来自6个随机试验的个人参与者数据的二次分析 (SCOPE联盟).
  • 包括PFO和密码性中风的年轻人和中年成年人.
  • 通过透导管PFO关闭加上抗血栓治疗与单独抗血栓治疗的比较.

主要成果:

  • 帕斯卡系统将37%的患者归类为可能的,48.4%为可能的,14.6%为不可能的PFO相关中风.
  • 被归类为可能或可能的PFO相关中风的患者经历了关闭的净益 (较少的中风与增加的AF).
  • 被归类为不太可能发生PFO相关中风的患者经历了净伤害 (没有中风减少,AF增加).

结论:

  • 帕斯卡分类系统有效地区分了可能受益于PFO关闭的患者.
  • 它确定了5个患者中的4个 (可能/可能的组) 获得净收益.
  • 它确定了五分之一的患者 (不太可能的组),他们面临着因关闭而造成净伤害的风险.