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Updated: Jan 28, 2026

Using the E1A Minigene Tool to Study mRNA Splicing Changes
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致癌性SF3B1突变改变了mRNA非编码区域的拼接,从而诱导了新的治疗脆弱性

Michal Sekrecki1, Agata Sekrecka1, Rohan R Lattupally1

  • 1Stanford University School of Medicine, Stanford, California, United States.

Blood
|January 26, 2026
PubMed
概括

癌症中的SF3B1突变改变mRNA未翻译区域,增加DCAF16蛋白. 这一发现使得针对SF3B1突变癌症和慢性淋巴细胞白血病 (CLL) 的向治疗成为可能.

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